CKR-10 Antibody (E-2): sc-365957
- CKR-10 Antibody (E-2) is a mouse monoclonal IgG1 κ CKR-10 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 141-290 mapping within an internal region of CKR-10 of human origin
- CKR-10 Antibody (E-2) is recommended for detection of CKR-10 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CKR-10 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CKR-10 Antibody (E-2) for WB and IHC(P) applications. These reagents are now offered in bundles with CKR-10 Antibody (E-2) (see ordering information below).
CKR-10 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects CKR-10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CKR-10 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CKR-10, also known as CCR10 or GPR2, plays a crucial role in the immune system as a specific receptor for chemokines CCL27 and CCL28, which are involved in T cell recruitment to inflammation sites and skin homeostasis. CKR-10 gene is located on human chromosome 7q21 and shows high expression in testis, small intestine, fetal lung, and fetal kidney, indicating importance during development. CKR-10 expression appears at lower levels in adult tissues, including melanocytes, dermal fibroblasts, and dermal microvascular endothelial cells, suggesting involvement in skin-related immune responses and maintenance of skin integrity. CKR-10′s ability to mediate chemotaxis highlights significance in directing immune cell migration, essential for effective immune surveillance and response to inflammatory stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CKR-10 Antibody (E-2) References:
- Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine. | Jarmin, DI., et al. 2000. J Immunol. 164: 3460-4. PMID: 10725696
- Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). | Homey, B., et al. 2000. J Immunol. 164: 3465-70. PMID: 10725697
- Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). | Wang, W., et al. 2000. J Biol Chem. 275: 22313-23. PMID: 10781587
- Increasing sensor flexibility through neuromodulation. | Birmingham, JT. 2001. Biol Bull. 200: 206-10. PMID: 11341585
- Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1. | Adhikari, A. and Sprang, SR. 2003. J Biol Chem. 278: 51825-32. PMID: 14530282
- Differential diagnosis of Goatpox virus in Taiwan by multiplex polymerase chain reaction assay and high-resolution melt analysis. | Chan, KW., et al. 2014. J Vet Diagn Invest. 26: 195-202. PMID: 24567543
- Dual modulatory effects on feedback from a proprioceptor in the crustacean stomatogastric nervous system. | Grininger, D. and Birmingham, JT. 2021. J Neurophysiol. 125: 1755-1767. PMID: 33760675
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. | Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
- Identification of a major co-receptor for primary isolates of HIV-1. | Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. | Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
- CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. | Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. | Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CKR-10 Antibody (E-2) | sc-365957 | 200 µg/ml | $316.00 | |||
CKR-10 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-529527 | 200 µg Ab; 10 µg BP | $354.00 | |||
CKR-10 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-522443 | 200 µg Ab, 40 µg BP | $354.00 | |||
CKR-10 Antibody (E-2) AC | sc-365957 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CKR-10 Antibody (E-2) HRP | sc-365957 HRP | 200 µg/ml | $316.00 | |||
CKR-10 Antibody (E-2) FITC | sc-365957 FITC | 200 µg/ml | $330.00 | |||
CKR-10 Antibody (E-2) PE | sc-365957 PE | 200 µg/ml | $343.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 488 | sc-365957 AF488 | 200 µg/ml | $357.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 546 | sc-365957 AF546 | 200 µg/ml | $357.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 594 | sc-365957 AF594 | 200 µg/ml | $357.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 647 | sc-365957 AF647 | 200 µg/ml | $357.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 680 | sc-365957 AF680 | 200 µg/ml | $357.00 | |||
CKR-10 Antibody (E-2) Alexa Fluor® 790 | sc-365957 AF790 | 200 µg/ml | $357.00 |