CKAP2 Antibody (D-12): sc-393629

CKAP2 Antibody (D-12) is a mouse monoclonal IgG1 antibody that detects CKAP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CKAP2, also known as cytoskeleton associated protein 2, LB1, TMAP, or se20-10, is a 682 amino acid protein that plays a crucial role in the regulation of microtubules and the cell cycle, particularly during mitosis. CKAP2 is primarily localized in the cytoplasm and is expressed in various human tissues, including the thymus and testis. CKAP2 is essential for proper spindle function and cytokinesis, as CKAP2 is involved in the dynamic regulation of microtubules during cell division. Notably, CKAP2 is subject to post-translational modifications, particularly phosphorylation and dephosphorylation, which are critical for function. The phosphorylation of CKAP2 can lead to the activation of p53, resulting in the arrest of the G1 phase of the cell cycle and promoting apoptosis. Dysregulation of CKAP2 has been implicated in the development of gastric tumors, where overexpression may contribute to unregulated spindle functions and cancer progression. Anti-CKAP2 antibody (D-12) is a valuable tool for researchers studying the intricate mechanisms of cell division and the role of CKAP2 in cancer biology.

The preferred CKAP2 antibody is CKAP2 Antibody (B-12): sc-398286.