citrate synthase Antibody (E-2): sc-515640
- citrate synthase Antibody (E-2) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 145-170 within an internal region of citrate synthase of human origin
- recommended for detection of citrate synthase of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for citrate synthase Antibody (E-2) for WB and IHC(P) applications. These reagents are now offered in bundles with citrate synthase Antibody (E-2) (see ordering information below).
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Citrate synthase Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects citrate synthase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Citrate synthase is a crucial 466 amino acid protein located in the mitochondrial matrix, serving as the first and rate-limiting enzyme of the tricarboxylic acid cycle, which is vital for cellular respiration and energy production. Anti-citrate synthase antibody (E-2) catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate, a key intermediate in the metabolic pathway that not only fuels the production of ATP but also plays a significant role in the conversion of glucose to lipids, thereby influencing energy storage and utilization. Citrate synthase monoclonal antibody (E-2) extends beyond metabolic functions and is implicated in various diseases linked to mitochondrial dysfunction, including metabolic disorders and certain types of cancer. The gene encoding citrate synthase is located on human chromosome 12q13.2 and produces two alternatively spliced variants, CSa and CSb, which may have distinct regulatory roles in metabolism. With broad species reactivity and versatility in multiple applications, citrate synthase (E-2) antibody is an essential tool for researchers investigating mitochondrial function and related metabolic pathways.
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citrate synthase Antibody (E-2) References:
- STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth. | MacPherson, S., et al. 2017. Cell Rep. 19: 910-918. PMID: 28467904
- Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase. | Schlachter, CR., et al. 2019. Biol Chem. 400: 1567-1581. PMID: 31141475
- Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. | Kang, W., et al. 2020. Lab Invest. 100: 583-595. PMID: 31857692
- Citrate synthase desuccinylation by SIRT5 promotes colon cancer cell proliferation and migration. | Ren, M., et al. 2020. Biol Chem. 401: 1031-1039. PMID: 32284438
- Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase. | Verstraete, K., et al. 2021. Nat Struct Mol Biol. 28: 636-638. PMID: 34294920
- Melatonin inhibits Gram-negative pathogens by targeting citrate synthase. | He, F., et al. 2022. Sci China Life Sci. 65: 1430-1444. PMID: 35000061
- Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice. | Kang, W., et al. 2022. MicroPubl Biol. 2022: PMID: 35663411
- Effect of downregulated citrate synthase on oxidative phosphorylation signaling pathway in HEI-OC1 cells. | Xu, X., et al. 2022. Proteome Sci. 20: 14. PMID: 36071491
- Citrate synthase lysine K215 hypoacetylation contributes to microglial citrate accumulation and pro-inflammatory functions after traumatic brain injury. | Zhang, F., et al. 2024. CNS Neurosci Ther. 30: e14567. PMID: 38421106
- β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation. | He, JK., et al. 2024. J Cardiovasc Transl Res.. PMID: 39499445
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
citrate synthase Antibody (E-2) | sc-515640 | 200 µg/ml | $322.00 | |||
citrate synthase Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-538810 | 200 µg Ab; 10 µg BP | $361.00 | |||
citrate synthase Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-536484 | 200 µg Ab; 40 µg BP | $361.00 | |||
citrate synthase Antibody (E-2): m-IgG2a BP-HRP Bundle | sc-548416 | 200 µg Ab; 10 µg BP | $361.00 | |||
citrate synthase (E-2) Neutralizing Peptide | sc-515640 P | 100 µg/0.5 ml | $69.00 |