CIP4 Antibody (G-2): sc-166809

CIP4 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects CIP4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CIP4, also known as Cdc42-interacting protein 4 or TRIP10, is a 601 amino acid protein that plays a crucial role in the insulin-dependent translocation of Glut4 to the plasma membrane, which is vital for glucose uptake and metabolism. CIP4 is predominantly localized in the cytoplasm and cytoskeleton, as well as in the lysosome and Golgi apparatus, where CIP4 facilitates the coordination of membrane tubulation with actin cytoskeletal reorganization during endocytosis. The presence of one FCH domain, one SH3 domain, and one REM repeat in CIP4′s structure allows interactions with various signaling pathways, making CIP4 essential for cellular processes such as membrane trafficking and cytoskeletal dynamics. Notably, CIP4 exists in multiple alternatively spliced isoforms and undergoes post-translational modifications, including tyrosine phosphorylation, which can influence function and interactions. Aberrant splicing of CIP4 has been linked to the pathogenesis of renal cell carcinoma, highlighting CIP4′s potential role in tumor transformation and metastasis. With diverse applications and significant biological implications, anti-CIP4 antibody (G-2) is an invaluable tool for researchers studying glucose metabolism, endocytosis, and cancer biology.

The preferred CIP4 antibody is CIP4 Antibody (F-10): sc-166810.