Chitotriosidase Antibody (A-11): sc-271460

Chitotriosidase Antibody (A-11) is a mouse monoclonal IgM antibody that detects Chitotriosidase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Chitotriosidase antibody (A-11) is available as a non-conjugated format. Chitotriosidase, also known as CHIT1, plays a crucial role in degrading chitin, a polysaccharide found in arthropod exoskeletons and fungal cell walls. CHIT1 enzymatic activity helps combat chitin-containing pathogens, contributing to host defense mechanisms. Chitotriosidase is predominantly secreted by activated macrophages, and elevated plasma levels often indicate various pathological conditions, including Gaucher disease. Chitotriosidase expression in mice localizes to brain, skin, bone marrow, kidney, tongue, stomach, and testis, highlighting roles in both local and systemic immune responses. Structural similarities between Chitotriosidase and chitinases from lower organisms underscore evolutionary significance and functional conservation across species.

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Chitotriosidase Antibody (A-11) References:

1. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation.  |  Zhu, Z., et al. 2004. Science. 304: 1678-82. PMID: 15192232
2. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease.  |  Brinkman, J., et al. 2005. J Inherit Metab Dis. 28: 13-20. PMID: 15702402
3. Identification and use of biomarkers in Gaucher disease and other lysosomal storage diseases.  |  Aerts, JM., et al. 2005. Acta Paediatr Suppl. 94: 43-6; discussion 37-8. PMID: 15895711
4. Clinical evaluation of biomarkers in Gaucher disease.  |  Deegan, PB. and Cox, TM. 2005. Acta Paediatr Suppl. 94: 47-50; discussion 37-8. PMID: 15895712
5. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages.  |  Di Rosa, M., et al. 2005. Clin Chem Lab Med. 43: 499-502. PMID: 15899671
6. Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages.  |  Malaguarnera, L., et al. 2005. J Clin Lab Anal. 19: 128-32. PMID: 15900564
7. Marked differences in tissue-specific expression of chitinases in mouse and man.  |  Boot, RG., et al. 2005. J Histochem Cytochem. 53: 1283-92. PMID: 15923370
8. Kinetic characterization of recombinant human acidic mammalian chitinase.  |  Chou, YT., et al. 2006. Biochemistry. 45: 4444-54. PMID: 16584180
9. Serum chitotriosidase activity in acute coronary syndrome.  |  Yildiz, BS., et al. 2013. J Atheroscler Thromb. 20: 134-41. PMID: 22986554
10. Clinical significance of chitotriosidase in outpatients with advanced heart failure.  |  Cetin Sanlialp, S., et al. 2021. J Investig Med. 69: 736-741. PMID: 33272933
11. Chitotriosidase as biomarker for early stage amyotrophic lateral sclerosis: a multicenter study.  |  Steinacker, P., et al. 2021. Amyotroph Lateral Scler Frontotemporal Degener. 22: 276-286. PMID: 33576252
12. The role of serum and bronchoalveolar lavage fluid chitotriosidase activity on diagnosis, disease characteristics and prognosis of sarcoidosis.  |  Köycü Buhari, G., et al. 2023. Tuberk Toraks. 71: 367-377. PMID: 38152007

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Chitotriosidase Antibody (A-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Chitotriosidase Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Chitotriosidase Antibody (A-11) Specifications

Alternate Product Name: Chitotriosidase

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 150-215

Epitope Target: Chitotriosidase

Epitope Species: human

Product Reactivity/Detection: Chitotriosidase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Chitotriosidase Antibody (A-11): N/A