ChemR23 Antibody (C-7): sc-374570

ChemR23 Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects ChemR23 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ChemR23 (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. ChemR23, also known as chemokine receptor-like 1, is a member of the G protein-coupled receptor family and plays a crucial role in immune responses by acting as a receptor for specific chemokines, which are vital for leukocyte migration and adhesion. ChemR23 is predominantly located in the cell membrane, where positioning is essential for function as a receptor, allowing interaction with extracellular signals and initiation of intracellular signaling pathways. This interaction is particularly important in inflammatory responses and tissue homeostasis, as ChemR23 helps regulate immune cell movement to sites of injury or infection. Additionally, ChemR23 has been implicated in various diseases, including a role as a co-receptor for certain strains of simian immunodeficiency virus and HIV-1, highlighting significance in both normal physiology and disease pathology. Anti-ChemR23 antibody (C-7)′s ability to detect ChemR23 across multiple species makes this reagent an invaluable tool for researchers studying immune mechanisms and receptor signaling pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ChemR23 Antibody (C-7) References:

1. Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23.  |  Meder, W., et al. 2003. FEBS Lett. 555: 495-9. PMID: 14675762
2. An unappreciated role for RNA surveillance.  |  Hillman, RT., et al. 2004. Genome Biol. 5: R8. PMID: 14759258
3. Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.  |  Vermi, W., et al. 2005. J Exp Med. 201: 509-15. PMID: 15728234
4. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.  |  Arita, M., et al. 2005. J Exp Med. 201: 713-22. PMID: 15753205
5. Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity.  |  Wittamer, V., et al. 2005. J Immunol. 175: 487-93. PMID: 15972683
6. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner.  |  Cash, JL., et al. 2010. J Immunol. 184: 5315-24. PMID: 20363975
7. The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo.  |  Bondue, B., et al. 2012. PLoS One. 7: e40043. PMID: 22768214
8. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury through ChemR23.  |  Cash, JL., et al. 2013. EMBO Rep. 14: 999-1007. PMID: 23999103
9. Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.  |  Peyrassol, X., et al. 2016. J Immunol. 196: 2893-901. PMID: 26864035
10. The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells.  |  Kumar, JD., et al. 2016. Br J Cancer. 114: 1152-9. PMID: 27092781
11. Chemerin/ChemR23 axis triggers an inflammatory response in keratinocytes through ROS-sirt1-NF-κB signaling.  |  Wang, Y., et al. 2019. J Cell Biochem. 120: 6459-6470. PMID: 30426542
12. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains.  |  Samson, M., et al. 1998. Eur J Immunol. 28: 1689-700. PMID: 9603476

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ChemR23 Antibody (C-7) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-ChemR23 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ChemR23 Antibody (C-7) Specifications

Alternate Product Name: ChemR23

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 273-305

Epitope Target: ChemR23

Epitope Species: human

Product Reactivity/Detection: ChemR23

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for ChemR23 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin