ChemR23 Antibody (BZ332): sc-33726
- ChemR23 Antibody (BZ332) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against an N-terminal peptide comprised of ChemR23 of CMKLR1 of human origin
- recommended for detection of ChemR23 of human origin by FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ChemR23 Antibody (BZ332). This work is in progress.
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ChemR23 Antibody (BZ332) is a rat monoclonal IgG antibody that detects ChemR23 in human samples through flow cytometry (FCM). ChemR23, also known as chemokine receptor-like 1, is a member of the G protein-coupled receptor family and plays a crucial role in various physiological processes, including immune response and tissue development. This integral membrane protein is primarily located in developing osseous and cartilaginous tissues, as well as in the brain, kidney, gastrointestinal tissues, and myeloid tissue, highlighting ChemR23′s importance in both embryonic development and adult tissue homeostasis. ChemR23′s expression in these diverse tissues suggests involvement in mediating chemotactic responses and regulating cellular migration, which is vital for maintaining tissue integrity and responding to injury or infection. Additionally, ChemR23 acts as a co-receptor for various strains of simian immunodeficiency virus (SIV) and a primary strain of HIV-1, indicating potential roles in viral pathogenesis and immune system response to viral infections. Anti-ChemR23 antibody (BZ332) is an essential tool for researchers studying the dynamics of immune cell migration and ChemR23′s implications in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ChemR23 Antibody (BZ332) References:
- Consequences of ChemR23 heteromerization with the chemokine receptors CXCR4 and CCR7. | de Poorter, C., et al. 2013. PLoS One. 8: e58075. PMID: 23469143
- Chemerin/chemR23 axis in inflammation onset and resolution. | Mariani, F. and Roncucci, L. 2015. Inflamm Res. 64: 85-95. PMID: 25548799
- ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. | Herová, M., et al. 2015. J Immunol. 194: 2330-7. PMID: 25637017
- ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages. | Laguna-Fernandez, A., et al. 2018. Circulation. 138: 1693-1705. PMID: 29739755
- The G-protein coupled receptor ChemR23 determines smooth muscle cell phenotypic switching to enhance high phosphate-induced vascular calcification. | Carracedo, M., et al. 2019. Cardiovasc Res. 115: 1557-1566. PMID: 30597013
- Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy. | Shang, J., et al. 2019. J Cell Mol Med. 23: 3417-3428. PMID: 30784180
- Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on obesity-related vascular dysfunction. | Xie, Y. and Liu, L. 2022. J Transl Med. 20: 141. PMID: 35317838
- ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression. | Lavy, M., et al. 2023. Front Immunol. 14: 1196731. PMID: 37539056
- ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis. | Zhang, Y., et al. 2023. Cell Death Dis. 14: 721. PMID: 37932279
- ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke. | Liu, L., et al. 2024. J Transl Med. 22: 23. PMID: 38178174
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ChemR23 Antibody (BZ332) | sc-33726 | 200 µg/ml | $322.00 | |||
ChemR23 Antibody (BZ332) Alexa Fluor® 488 | sc-33726 AF488 | 200 µg/ml | $364.00 | |||
ChemR23 Antibody (BZ332) Alexa Fluor® 647 | sc-33726 AF647 | 200 µg/ml | $364.00 | |||
ChemR23 Antibody (BZ332) FITC | sc-33726 FITC | 200 µg/ml | $336.00 | |||
ChemR23 Antibody (BZ332) PE | sc-33726 PE | 200 µg/ml | $349.00 |