CHD6 Antibody (E-6): sc-393445

CHD6 Antibody (E-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects CHD6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHD6 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CHD6 protein, also known as chromodomain-helicase-DNA-binding protein 6, is a crucial component in the regulation of chromatin structure and function, playing a significant role in DNA repair and gene expression. CHD6 is a large protein consisting of 2,715 amino acids and is encoded by the human gene CHD6. As a member of the Snf2/Rad54 helicase family, CHD6 features two chromodomains, an ATP-binding helicase domain, and a C-terminal helicase domain, which are essential for ATP-dependent chromatin remodeling activity. The chromodomains facilitate the recognition and binding of methylated lysine residues on histones, thereby influencing chromatin accessibility and transcriptional regulation. This interaction is vital for maintaining genomic stability and responding to DNA damage, underscoring the importance of CHD6 in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CHD6 Antibody (E-6) References:

1. Mammalian chromodomain proteins: their role in genome organisation and expression.  |  Jones, DO., et al. 2000. Bioessays. 22: 124-37. PMID: 10655032
2. Identification and analysis of chromodomain-containing proteins encoded in the mouse transcriptome.  |  Tajul-Arifin, K., et al. 2003. Genome Res. 13: 1416-29. PMID: 12819141
3. Early pattern of epilepsy in the ring chromosome 20 syndrome.  |  Ville, D., et al. 2006. Epilepsia. 47: 543-9. PMID: 16529619
4. Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of gamma-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity.  |  Wang, HP., et al. 2006. Int J Radiat Biol. 82: 181-90. PMID: 16638715
5. Trisomy 20 mosaicism and nonmosaic trisomy 20: a report of 2 cases.  |  Joó, JG., et al. 2006. J Reprod Med. 51: 209-12. PMID: 16674019
6. CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis.  |  Lutz, T., et al. 2006. FEBS Lett. 580: 5851-7. PMID: 17027977
7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.  |  Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
8. Ring chromosome 20 syndrome without deletions of the subtelomeric and CHRNA4--KCNQ2 genes loci.  |  Elghezal, H., et al. 2007. Eur J Med Genet. 50: 441-5. PMID: 17851150

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHD6 Antibody (E-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CHD6 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHD6 Antibody (E-6) Specifications

Alternate Product Name: CHD6

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 243-320

Epitope Target: CHD6

Epitope Species: human

Product Reactivity/Detection: CHD6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CHD6 Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent