CGRP-RCP Antibody (D-1): sc-393347

CGRP-RCP Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects CGRP-RCP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CGRP-RCP antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CGRP-RCP plays a crucial role in the signaling pathways of calcitonin gene-related peptide (CGRP), which is vital for various physiological processes, including the modulation of pain and inflammation. CGRP-RCP is primarily located in CGRP-responsive tissues, where CGRP-RCP acts as an accessory protein that couples the CGRP receptor to downstream signaling effectors, thereby amplifying the biological effects of CGRP. This interaction is particularly important in reproductive tissues, where CGRP-RCP is associated with the acrosome, influencing reproductive functions. The regulation of CGRP-RCP expression and interactions with other proteins can significantly impact reproductive health and the body′s response to pain, making CGRP-RCP a valuable target for research and therapeutic applications.

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CGRP-RCP Antibody (D-1) References:

1. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein.  |  Balkan, W., et al. 1999. Endocrinology. 140: 1459-69. PMID: 10067875
2. Equipotent in vitro actions of alpha- and beta-CGRP on guinea pig basilar artery are likely to be mediated via CRLR derived CGRP receptors.  |  Sams, A., et al. 1999. Regul Pept. 85: 67-75. PMID: 10651059
3. Sensitivity of myometrium to CGRP varies during mouse estrous cycle and in response to progesterone.  |  Naghashpour, M. and Dahl, G. 2000. Am J Physiol Cell Physiol. 278: C561-9. PMID: 10712245
4. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors.  |  Evans, BN., et al. 2000. J Biol Chem. 275: 31438-43. PMID: 10903324
5. Calcitonin gene-related peptide-receptor component protein expression in the uterine cervix, lumbosacral spinal cord, and dorsal root ganglia.  |  Pokabla, MJ., et al. 2002. Peptides. 23: 507-14. PMID: 11836000
6. Regulation and function of the CGRP receptor complex in human granulopoiesis.  |  Harzenetter, MD., et al. 2002. Exp Hematol. 30: 306-12. PMID: 11937264
7. An Rpb4/Rpb7-like complex in yeast RNA polymerase III contains the orthologue of mammalian CGRP-RCP.  |  Siaut, M., et al. 2003. Mol Cell Biol. 23: 195-205. PMID: 12482973
8. Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration.  |  Goharkhay, N., et al. 2007. Am J Perinatol. 24: 497-500. PMID: 17853344
9. Involvement of CGRP-RCP in the caveolin-1/ERK1/2 signal pathway in the static pressure-induced proliferation of vascular smooth muscle cells.  |  Guo, F., et al. 2018. J Cell Physiol. 233: 6910-6920. PMID: 29741760
10. Loss of Calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias 'gepant' antagonism.  |  Rahman, SM., et al. 2024. bioRxiv.. PMID: 39484482
11. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay.  |  Luebke, AE., et al. 1996. Proc Natl Acad Sci U S A. 93: 3455-60. PMID: 8622957
12. Inhibitory effect of calcitonin gene-related peptide on myometrial contractility is diminished at parturition.  |  Naghashpour, M., et al. 1997. Endocrinology. 138: 4207-14. PMID: 9322931

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CGRP-RCP Antibody (D-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CGRP-RCP Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CGRP-RCP Antibody (D-1) Specifications

Alternate Product Name: CGRP-RCP

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-148

Epitope Target: CGRP-RCP

Epitope Species: human

Product Reactivity/Detection: CGRP-RCP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CGRP-RCP Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin