CGBP Antibody (35): sc-136419

CGBP Antibody (35) is a mouse monoclonal IgG1 kappa light chain antibody that detects CGBP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-CGBP antibody (35) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). CGBP protein plays a crucial role in gene regulation, specifically by binding to unmethylated CpG dinucleotides found in CpG islands, which are essential for modulating gene expression. These islands are often located in promoter regions of genes and are critical for the recruitment of transcription factors, thereby influencing the transcriptional activity of associated genes. CGBP (35) monoclonal antibody enables researchers to study how CGBP acts as a transcriptional activator in cellular processes such as differentiation and development. Additionally, the CXXC domain of CGBP, which is conserved among various DNA-binding proteins, underscores its evolutionary significance and functional relevance in maintaining genomic integrity. Anti-CGBP antibody (35) serves as an invaluable tool for researchers studying gene expression regulation and the molecular mechanisms underlying epigenetic modifications.

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CGBP Antibody (35) References:

1. Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.  |  Voo, KS., et al. 2000. Mol Cell Biol. 20: 2108-21. PMID: 10688657
2. The housekeeping promoter from the mouse CpG island HTF9 contains multiple protein-binding elements that are functionally redundant.  |  Somma, MP., et al. 1991. Nucleic Acids Res. 19: 2817-24. PMID: 1711672
3. In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1.  |  Pfeifer, GP., et al. 1990. Genes Dev. 4: 1277-87. PMID: 2227409
4. DNA methyltransferases.  |  Bestor, TH. and Verdine, GL. 1994. Curr Opin Cell Biol. 6: 380-9. PMID: 7917329
5. Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.  |  Ma, Q., et al. 1993. Proc Natl Acad Sci U S A. 90: 6350-4. PMID: 8327517
6. An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands.  |  Macleod, D., et al. 1998. Mol Cell Biol. 18: 4433-43. PMID: 9671453

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CGBP Antibody (35) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CGBP Antibody (35) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CGBP Antibody (35) Specifications

Alternate Product Name: CGBP

Product Clone Name: 35

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 218-340

Epitope Target: CGBP

Epitope Species: human

Product Reactivity/Detection: CGBP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CGBP Antibody (35): AC: Agarose, HRP: Horseradish Peroxidase, X: TransCruz Reagent