cerberus Antibody (C-1): sc-515324
- cerberus Antibody (C-1) is a mouse monoclonal IgG2a κ cerberus antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 152-175 within an internal region of cerberus of human origin
- cerberus Antibody (C-1) is recommended for detection of cerberus of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-cerberus Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cerberus Antibody (C-1) for WB applications. These reagents are now offered in bundles with cerberus Antibody (C-1) (see ordering information below).
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Cerberus Antibody (C-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects cerberus protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-cerberus antibody (C-1) comes in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. Cerberus protein, also known as Cer1 or Cerr, belongs to the cysteine knot superfamily and is mainly expressed in anterior gastrula regions during embryonic development. Cerberus (C-1) monoclonal antibody plays a key role in detecting proteins involved in head structure differentiation, which is essential for proper craniofacial development. Cerberus protein shows segmental expression in nascent and newly formed somites, suggesting significant involvement in axial skeleton, musculature, and peripheral nervous system development. As a secreted protein, cerberus functions in the extracellular space, inhibiting signaling molecules and modulating developmental pathways. Neural-inducing and mesoderm-inhibiting activities of cerberus result from specific binding to bone morphogenetic protein (BMP) and Nodal molecules. In mice, cerberus expression occurs in the anterior mesendoderm beneath the presumptive anterior neural plate, highlighting its role in early neural development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
cerberus Antibody (C-1) References:
- The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. | Simpson, EH., et al. 1999. Dev Biol. 213: 202-6. PMID: 10452857
- The organizer factors Chordin and Noggin are required for mouse forebrain development. | Bachiller, D., et al. 2000. Nature. 403: 658-61. PMID: 10688202
- [The head inducer Cerberus in a multivalent extracellular inhibitor]. | Agius, PE., et al. 1999. J Soc Biol. 193: 347-54. PMID: 10689616
- Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. | Belo, JA., et al. 2000. Genesis. 26: 265-70. PMID: 10748465
- Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. | Shawlot, W., et al. 1998. Proc Natl Acad Sci U S A. 95: 6198-203. PMID: 9600941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
cerberus Antibody (C-1) | sc-515324 | 200 µg/ml | $316.00 | |||
cerberus Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-531338 | 200 µg Ab; 10 µg BP | $354.00 | |||
cerberus Antibody (C-1): m-IgGκ BP-HRP Bundle | sc-525003 | 200 µg Ab, 40 µg BP | $354.00 | |||
cerberus Antibody (C-1): m-IgG2a BP-HRP Bundle | sc-547767 | 200 µg Ab; 10 µg BP | $354.00 | |||
cerberus Antibody (C-1) AC | sc-515324 AC | 500 µg/ml, 25% agarose | $416.00 | |||
cerberus Antibody (C-1) HRP | sc-515324 HRP | 200 µg/ml | $316.00 | |||
cerberus Antibody (C-1) FITC | sc-515324 FITC | 200 µg/ml | $330.00 | |||
cerberus Antibody (C-1) PE | sc-515324 PE | 200 µg/ml | $343.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 488 | sc-515324 AF488 | 200 µg/ml | $357.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 546 | sc-515324 AF546 | 200 µg/ml | $357.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 594 | sc-515324 AF594 | 200 µg/ml | $357.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 647 | sc-515324 AF647 | 200 µg/ml | $357.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 680 | sc-515324 AF680 | 200 µg/ml | $357.00 | |||
cerberus Antibody (C-1) Alexa Fluor® 790 | sc-515324 AF790 | 200 µg/ml | $357.00 | |||
cerberus (C-1) Neutralizing Peptide | sc-515324 P | 100 µg/0.5 ml | $68.00 |