CEP97 Antibody (B-4): sc-515526

CEP97 Antibody (B-4) is a mouse monoclonal IgM antibody that detects CEP97 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CEP97 antibody (B-4) is available as the non-conjugated form. CEP97, also known as centrosomal protein of 97 kDa or LRRIQ2, is an 865 amino acid protein characterized by the presence of six leucine-rich repeat (LRR) motifs and one IQ domain, which facilitates interaction with calmodulin. CEP97 is primarily localized to the centrosome, where CEP97 plays a crucial role in cytokinesis and is essential for proper spindle formation during cell division. CEP97′s importance extends to recruiting CEP110, a key protein necessary for centrosomal duplication, thereby ensuring accurate cell division and maintaining genomic stability. Mutations in genes encoding proteins like CEP97 can lead to various human diseases, highlighting CEP97′s significance in cellular processes. Anti-CEP97 antibody (B-4) serves as an invaluable tool for studying centrosomal protein dynamics and their implications in health and disease.

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CEP97 Antibody (B-4) References:

1. The leucine-rich repeat as a protein recognition motif.  |  Kobe, B. and Kajava, AV. 2001. Curr Opin Struct Biol. 11: 725-32. PMID: 11751054
2. Centrosomes in cellular regulation.  |  Doxsey, S., et al. 2005. Annu Rev Cell Dev Biol. 21: 411-34. PMID: 16212501
3. Structural analysis of leucine-rich-repeat variants in proteins associated with human diseases.  |  Matsushima, N., et al. 2005. Cell Mol Life Sci. 62: 2771-91. PMID: 16231091
4. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.  |  Matsuoka, S., et al. 2007. Science. 316: 1160-6. PMID: 17525332
5. Cep97 and CP110 suppress a cilia assembly program.  |  Spektor, A., et al. 2007. Cell. 130: 678-90. PMID: 17719545
6. The extracellular leucine-rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns.  |  Dolan, J., et al. 2007. BMC Genomics. 8: 320. PMID: 17868438
7. Double life of centrioles: CP110 in the spotlight.  |  Bettencourt-Dias, M. and Carvalho-Santos, Z. 2008. Trends Cell Biol. 18: 8-11. PMID: 18068367
8. Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.  |  Nagai, T., et al. 2018. J Cell Sci. 131: PMID: 30404837
9. Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.  |  Dobbelaere, J., et al. 2020. Curr Biol. 30: 3045-3056.e7. PMID: 32589908
10. CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis.  |  Lee, M., et al. 2022. J Cell Biol. 221: PMID: 34787650
11. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.  |  Song, T., et al. 2022. EMBO Rep. 23: e54090. PMID: 35301795
12. The leucine-rich repeat: a versatile binding motif.  |  Kobe, B. and Deisenhofer, J. 1994. Trends Biochem Sci. 19: 415-21. PMID: 7817399

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEP97 Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CEP97 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEP97 Antibody (B-4) Specifications

Alternate Product Name: CEP97

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 823-842

Epitope Target: CEP97

Epitope Species: human

Product Reactivity/Detection: CEP97

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CEP97 Antibody (B-4): P: Blocking Peptide