CEP55 Antibody (C-4): sc-377018

CEP55 Antibody (C-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects CEP55 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CEP55 antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEP55, or centrosomal protein of 55 kDa, is a 464 amino acid protein that plays a crucial role in cell division by localizing to the centrosome during interphase and redistributing throughout the cell during mitosis. CEP55 interacts with key centrosome components for proper mitotic exit and cytokinesis. Several phosphorylation events during the cell cycle regulate CEP55 activity. Disruptions in CEP55 can lead to mitotic failure and have been linked to tumor progression, highlighting CEP55′s importance in cancer biology. Two isoforms of CEP55 arise from alternative splicing, further diversifying functional roles in cellular processes.

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CEP55 Antibody (C-4) References:

1. The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma.  |  Inoda, S., et al. 2011. Exp Mol Pathol. 90: 55-60. PMID: 20950610
2. CEP55 promotes epithelial-mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR pathway.  |  Chen, H., et al. 2019. Clin Transl Oncol. 21: 939-949. PMID: 30607788
3. CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251.  |  Li, F., et al. 2019. Neurosci Lett. 705: 80-86. PMID: 31005653
4. Cep55 overexpression promotes genomic instability and tumorigenesis in mice.  |  Sinha, D., et al. 2020. Commun Biol. 3: 593. PMID: 33087841
5. MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.  |  Hua, R., et al. 2021. Reprod Sci. 28: 595-602. PMID: 33095425
6. The RNA-helicase DDX21 upregulates CEP55 expression and promotes neuroblastoma.  |  Putra, V., et al. 2021. Mol Oncol. 15: 1162-1179. PMID: 33497018
7. Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.  |  Rashidieh, B., et al. 2021. PLoS Genet. 17: e1009334. PMID: 34710087
8. α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.  |  Tang, Y., et al. 2023. Cell Commun Signal. 21: 162. PMID: 37381005
9. Cancer-testis antigen CEP55 serves as a prognostic biomarker and is correlated with immune infiltration and immunotherapy efficacy in pan-cancer.  |  Xie, X., et al. 2023. Front Mol Biosci. 10: 1198557. PMID: 37484531
10. Centrosomal Protein 55 (CEP55) Drives Immune Exclusion and Resistance to Immune Checkpoint Inhibitors in Colorectal Cancer.  |  Wangmo, D., et al. 2024. Vaccines (Basel). 12: PMID: 38250876

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEP55 Antibody (C-4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CEP55 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEP55 Antibody (C-4) Specifications

Alternate Product Name: CEP55

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 163-462

Epitope Target: CEP55

Epitope Species: mouse

Product Reactivity/Detection: CEP55

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CEP55 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CEP55 antibody is CEP55 Antibody (B-8): sc-374051.