CEP290 Antibody (B-7): sc-390462

CEP290 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CEP290 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CEP290 antibody (B-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEP290 protein, also known as centrosomal protein of 290 kDa, plays a crucial role in the assembly and function of centrosomes, which are essential for proper cell division and organization of microtubules. Specifically, CEP290 is involved in the localization of ciliary and phototransduction proteins in retinal photoreceptor cells, making CEP290 vital for vision. Disruptions in the function of CEP290 due to mutations can lead to severe genetic disorders, including Joubert syndrome type 5, Senior-Løken syndrome type 6, Leber congenital amaurosis type 10, and Meckel syndrome type 4, highlighting the importance of CEP290 in maintaining cellular integrity and function. CEP290 (B-7) antibody′s ability to effectively detect and quantify CEP290 makes this monoclonal antibody an invaluable tool for researchers studying centrosome biology and related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CEP290 Antibody (B-7) References:

1. Centriole duplication and maturation in animal cells.  |  Lange, BM., et al. 2000. Curr Top Dev Biol. 49: 235-49. PMID: 11005021
2. Centrosome maturation.  |  Palazzo, RE., et al. 2000. Curr Top Dev Biol. 49: 449-70. PMID: 11005031
3. Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome.  |  Valente, EM., et al. 2006. Nat Genet. 38: 623-5. PMID: 16682970
4. The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.  |  Sayer, JA., et al. 2006. Nat Genet. 38: 674-81. PMID: 16682973
5. Centriole assembly in Caenorhabditis elegans.  |  Pelletier, L., et al. 2006. Nature. 444: 619-23. PMID: 17136092
6. Mutation analysis of NPHP6/CEP290 in patients with Joubert syndrome and Senior-Løken syndrome.  |  Helou, J., et al. 2007. J Med Genet. 44: 657-63. PMID: 17617513
7. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis.  |  Zhu, F., et al. 2008. Curr Biol. 18: 136-41. PMID: 18207742
8. Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome.  |  Leitch, CC., et al. 2008. Nat Genet. 40: 443-8. PMID: 18327255
9. Leber congenital amaurosis: genes, proteins and disease mechanisms.  |  den Hollander, AI., et al. 2008. Prog Retin Eye Res. 27: 391-419. PMID: 18632300
10. CEP290, a gene with many faces: mutation overview and presentation of CEP290base.  |  Coppieters, F., et al. 2010. Hum Mutat. 31: 1097-108. PMID: 20690115
11. CEP290 and the primary cilium.  |  Drivas, TG. and Bennett, J. 2014. Adv Exp Med Biol. 801: 519-25. PMID: 24664739
12. Gene Editing for CEP290-Associated Retinal Degeneration.  |  Pierce, EA., et al. 2024. N Engl J Med. 390: 1972-1984. PMID: 38709228

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEP290 Antibody (B-7) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-CEP290 Antibody (B-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEP290 Antibody (B-7) Specifications

Alternate Product Name: CEP290

Product Clone Name: B-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1441-1740

Epitope Target: CEP290

Epitope Species: human

Product Reactivity/Detection: CEP290

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for CEP290 Antibody (B-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin