CEP290 Antibodies

Santa Cruz Biotechnology offers a broad range of CEP290 monoclonal antibodies for research in understanding CEP290 protein function. CEP290 monoclonal antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CEP290, also known as centrosomal protein 290 kDa, is essential for ciliary function and plays a significant role in the assembly and maintenance of cilia. Mutations in the CEP290 gene are associated with several ciliopathies, including Leber congenital amaurosis and other retinal degenerative diseases, highlighting its importance in vision and cellular signaling. Understanding CEP290 function is crucial for developing therapeutic strategies for these conditions. Research has shown that CEP290 localizes to the transition zone of primary cilia and regulates protein trafficking between the cell body and cilium. CEP290 also interacts with numerous proteins involved in ciliary transport and signaling pathways. Recent studies have revealed CEP290's role in photoreceptor development and maintenance, making it a key target for vision research. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance understanding of CEP290's role in human health and disease development.