Centaurin γ3 Antibody (E-11): sc-390362
- Centaurin γ3 Antibody (E-11) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 191-227 near the N-terminus of Centaurin γ3 of human origin
- recommended for detection of Centaurin γ3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine and porcine
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Centaurin γ3 Antibody (E-11) for WB applications. These reagents are now offered in bundles with Centaurin γ3 Antibody (E-11) (see ordering information below).
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Centaurin γ3 Antibody (E-11) is a mouse monoclonal IgG2a antibody that detects Centaurin γ3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Centaurin γ3 is a member of the Centaurin GTPase-activating protein family, which plays a crucial role in the regulation of ADP-ribosylation factor (ARF) proteins, particularly in vesicular transport and cytoskeletal organization. Centaurin γ3 is primarily localized in the cytoplasm and interacts with phosphoinositides, specifically PtdIns(3,4,5)P3, which is vital for cellular signaling pathways. By binding to PtdIns(3,4,5)P3, Centaurin γ3 can modulate ARF protein activity, thereby influencing membrane trafficking and cellular adhesion processes. Centaurin γ3′s role as a GTPase-activating protein for ARF6 highlights its importance in regulating receptor internalization and maintaining cellular homeostasis. Anti-Centaurin γ3 antibody (E-11) serves as an essential tool for researchers studying cellular transport and signaling mechanisms.
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Centaurin γ3 Antibody (E-11) References:
- AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. | Oku, Y. and Huganir, RL. 2013. J Neurosci. 33: 12586-98. PMID: 23904596
- BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma. | Kulkarni, A., et al. 2017. Clin Cancer Res. 23: 5631-5638. PMID: 28539463
- Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein. | Kruse, R., et al. 2017. Mol Cell Proteomics. 16: 1718-1735. PMID: 28550165
- CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. | Shimizu, D., et al. 2019. Anticancer Res. 39: 99-106. PMID: 30591445
- Exome sequencing identifies predisposing and fusion gene in ganglioneuroma, ganglioneuroblastoma and neuroblastoma. | Wu, W., et al. 2019. Math Biosci Eng. 16: 7217-7229. PMID: 31698611
- Critical role of CRAG, a splicing variant of centaurin-γ3/AGAP3, in ELK1-dependent SRF activation at PML bodies. | Nagashima, S., et al. 2019. Sci Rep. 9: 20107. PMID: 31882856
- Identification of fusions with potential clinical significance in melanoma. | Moran, JMT., et al. 2022. Mod Pathol. 35: 1837-1847. PMID: 35871080
- HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6. | Jiang, S., et al. 2024. Sci Bull (Beijing). 69: 173-178. PMID: 38071109
- Pulmonary Erdheim-Chester Disease With BRAF-AGAP3 Fusion: Late-Onset Osteolytic Femoral Lesions Despite Long-Term Pulmonary Stabilization With Corticosteroid. | Nishino, K., et al. 2024. Cureus. 16: e55670. PMID: 38586706
- Rare BRAF gene fusions in metastatic early-onset colon cancer: A case report. | Zhao, T., et al. 2024. Heliyon. 10: e40753. PMID: 39687148
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Centaurin γ3 Antibody (E-11) | sc-390362 | 200 µg/ml | $322.00 | |||
Centaurin γ3 Antibody (E-11): m-IgG Fc BP-HRP Bundle | sc-540789 | 200 µg Ab; 10 µg BP | $361.00 | |||
Centaurin γ3 Antibody (E-11): m-IgG2a BP-HRP Bundle | sc-546959 | 200 µg Ab; 10 µg BP | $361.00 | |||
Centaurin γ3 (E-11) Neutralizing Peptide | sc-390362 P | 100 µg/0.5 ml | $69.00 |