CEACAM6 Antibody (9A6): sc-59899

CEACAM6 Antibody (9A6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CEACAM6 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-CEACAM6 antibody (9A6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEACAM6, a member of the CD66 immunoglobulin superfamily, plays a crucial role in cell adhesion and is predominantly expressed in epithelial tissues, particularly in the context of tumorigenesis. CEACAM6 expression is significantly upregulated in various cancers, including colorectal cancer, where CEACAM6 is associated with tumor progression and metastasis. CEACAM6′s ability to mediate intercellular adhesion is vital for maintaining tissue architecture and regulating immune responses. CEACAM6 interacts with other proteins such as CEACAM1 and CEACAM5, which can influence cellular signaling pathways and contribute to the tumor microenvironment. Understanding CEACAM6 interactions and functions is essential for developing targeted therapies and diagnostic tools in oncology, making CEACAM6 (9A6) monoclonal antibody a valuable resource for researchers studying cancer biology and cell adhesion mechanisms.

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CEACAM6 Antibody (9A6) References:

1. Mutations in the carcinoembryonic antigen gene in colorectal cancer patients: implications on liver metastasis.  |  Zimmer, R. and Thomas, P. 2001. Cancer Res. 61: 2822-6. PMID: 11306451
2. Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19.  |  Tynan, K., et al. 1992. Nucleic Acids Res. 20: 1629-36. PMID: 1579453
3. Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.  |  Schrewe, H., et al. 1990. Mol Cell Biol. 10: 2738-48. PMID: 2342461
4. Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.  |  Barnett, TR., et al. 1989. J Cell Biol. 108: 267-76. PMID: 2537311
5. Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure.  |  Zimmermann, W., et al. 1987. Proc Natl Acad Sci U S A. 84: 2960-4. PMID: 3033671
6. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains.  |  Barnett, T., et al. 1988. Genomics. 3: 59-66. PMID: 3220478
7. Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect.  |  Chu, YD., et al. 2023. Cell Death Dis. 14: 660. PMID: 37816733
8. The emerging roles of CEACAM6 in human cancer (Review).  |  Wu, G., et al. 2024. Int J Oncol. 64: PMID: 38240103
9. Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models.  |  Nakazawa, Y., et al. 2024. Nat Commun. 15: 2192. PMID: 38467634
10. CEACAM6 expression and function in tumor biology: a comprehensive review.  |  Zhao, D., et al. 2024. Discov Oncol. 15: 186. PMID: 38796667
11. CD66 family members are associated with tyrosine kinase activity in human neutrophils.  |  Skubitz, KM., et al. 1995. J Immunol. 155: 5382-90. PMID: 7594554
12. Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins.  |  Barnett, TR., et al. 1993. Mol Cell Biol. 13: 1273-82. PMID: 8423792

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEACAM6 Antibody (9A6) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-CEACAM6 Antibody (9A6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEACAM6 Antibody (9A6) Specifications

Alternate Product Name: CEACAM6

Product Clone Name: 9A6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CEACAM6

Epitope Species: human

Product Reactivity/Detection: CEACAM6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for CEACAM6 Antibody (9A6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin