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CEACAM5 Antibody (26/5/1) - Western Blotting - Image 14583
CEACAM5 Antibody (26/5/1): sc-59873. Western blot analysis of CEACAM5 expression in LS1034 whole cell lysate under reducing (A) and non-reducing (B) conditions.
CEACAM5 Antibody (26/5/1) - Western Blotting - Image 14583
CEACAM5 Antibody (26/5/1): sc-59873. Western blot analysis of CEACAM5 expression in LS1034 whole cell lysate under reducing (A) and non-reducing (B) conditions.
CEACAM5 Antibody (26/5/1) - Western Blotting - Image 371551
CEACAM5 Antibody (26/5/1): sc-59873. Western blot analysis of CEACAM5 expression in COLO 205 whole cell lysate.
CEACAM5 Antibody (26/5/1): sc-59873. Western blot analysis of CEACAM5 expression in LS1034 whole cell lysate under reducing (A) and non-reducing (B) conditions.

CEACAM5 Antibody (26/5/1): sc-59873

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Datasheets
  • CEACAM5 Antibody (26/5/1) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
  • raised against CEA of human origin
  • recommended for detection of CEACAM5 of human origin by WB, IP, IF and FCM; non cross-reactive with CEACAM 1, 3, 4, 6, 7, and 8 or CD66f
  • available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • See CEACAM5 (CI-P83-1): sc-23928 for CEACAM5 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CEACAM5 Antibody (26/5/1) for WB applications. These reagents are now offered in bundles with CEACAM5 Antibody (26/5/1) (see ordering information below).

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SEE ALSO...

Additional CEACAM Antibodies including CEACAM1, CEACAM16, CEACAM19, CEACAM2, CEACAM20, CEACAM3, CEACAM6 and CEACAM7

CEACAM5 Antibody (26/5/1) is a mouse monoclonal IgG2a antibody that detects CEACAM5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CEACAM5, also known as carcinoembryonic antigen (CEA), plays a crucial role in cell adhesion and is predominantly expressed in epithelial tissues, particularly in the gastrointestinal tract. CEACAM5′s importance lies in its function as a tumor marker, as elevated levels are often associated with various malignancies, including colorectal cancer. CEACAM5′s glycosylation and GPI (glycosylphosphatidylinositol) anchoring contribute to stability and localization on the cell surface, facilitating intercellular interactions that are vital for maintaining tissue architecture and signaling. CEACAM5′s ability to mediate both homotypic and heterotypic adhesion events underscores significance in tumor progression and metastasis, making CEACAM5 a valuable target for diagnostic and therapeutic applications. Anti-CEACAM5 antibody (26/5/1) is an essential tool for researchers investigating cancer biology and biomarker potential for disease progression.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

CEACAM5 Antibody (26/5/1) References:

  1. CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates.  |  Govindan, SV., et al. 2009. Clin Cancer Res. 15: 6052-61. PMID: 19789330
  2. Selective and Concentrated Accretion of SN-38 with a CEACAM5-Targeting Antibody-Drug Conjugate (ADC), Labetuzumab Govitecan (IMMU-130).  |  Sharkey, RM., et al. 2018. Mol Cancer Ther. 17: 196-203. PMID: 29079710
  3. KRT19 and CEACAM5 mRNA-marked circulated tumor cells indicate unfavorable prognosis of breast cancer patients.  |  Wang, XM., et al. 2019. Breast Cancer Res Treat. 174: 375-385. PMID: 30535933
  4. A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo.  |  Baek, DS., et al. 2022. Cancer Lett. 525: 97-107. PMID: 34740610
  5. Identification of a CEACAM5 targeted nanobody for positron emission tomography imaging and near-infrared fluorescence imaging of colorectal cancer.  |  Xiao, Y., et al. 2023. Eur J Nucl Med Mol Imaging. 50: 2305-2318. PMID: 36914753
  6. Albumin binding improves nanobody pharmacokinetics for dual-modality PET/NIRF imaging of CEACAM5 in colorectal cancer models.  |  Song, W., et al. 2023. Eur J Nucl Med Mol Imaging. 50: 2591-2594. PMID: 37191678
  7. qRT-PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes-An improved method for assessment of tumor stage and prognosis.  |  Lindmark, G., et al. 2024. Int J Cancer. 154: 573-584. PMID: 37700602
  8. Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients.  |  Huang, SC., et al. 2024. Cancer Sci. 115: 270-282. PMID: 37942534
  9. Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody.  |  Seckinger, A., et al. 2024. Front Immunol. 15: 1378813. PMID: 38720892
  10. Wilms' Tumor 1-Associating Protein Promotes Nonsmall-Cell Lung Cancer Through the Expression of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5.  |  Liu, C., et al. 2024. Am J Clin Oncol. 47: 465-474. PMID: 38898559

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CEACAM5 Antibody (26/5/1)

sc-59873
200 µg/ml
$316.00

CEACAM5 Antibody (26/5/1): m-IgG Fc BP-HRP Bundle

sc-539147
200 µg Ab; 10 µg BP
$354.00

CEACAM5 Antibody (26/5/1): m-IgG2a BP-HRP Bundle

sc-546674
200 µg Ab; 10 µg BP
$354.00

CEACAM5 Antibody (26/5/1) FITC

sc-59873 FITC
200 µg/ml
$330.00

CEACAM5 Antibody (26/5/1) PE

sc-59873 PE
200 µg/ml
$343.00

How can CEACAM5 (26/5/1): sc-59873 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: DefinitelyNotMatt
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-59873 PE) or fluoroscein (sc-59873 FITC).
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of CEACAM5 expression in LS1034 whole cell lysate under reducing and non-reducing conditions. -SCBT QC
Date published: 2014-09-25
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CEACAM5 Antibody (26/5/1) is rated 5.0 out of 5 by 1.
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