CEACAM5/6 Antibody (By114): sc-20059
- CEACAM5/6 Antibody (By114) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against human B cell lymphoma
- recommended for detection of CEACAM5 and CEACAM6 of human origin by WB, IP, IF, IHC(P) and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CEACAM5 (CI-P83-1): sc-23928 for CEACAM5/6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CEACAM5/6 Antibody (By114) for WB and IHC(P) applications. These reagents are now offered in bundles with CEACAM5/6 Antibody (By114) (see ordering information below).
CEACAM5/6 Antibody (By114) is a mouse monoclonal IgG1 antibody that detects CEACAM5/6 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CEACAM5/6, part of the carcinoembryonic antigen (CEA) family, plays a crucial role in cell adhesion and signaling, which is vital for maintaining tissue architecture and facilitating intercellular communication. CEACAM5/6 is predominantly expressed in epithelial tissues and is known to be upregulated in various cancers, making anti-CEACAM5/6 antibody (By114) a significant marker for tumor progression and metastasis. CEACAM5/6 is located on the cell surface, where CEACAM5/6 participates in homotypic and heterotypic adhesion processes, influencing cellular interactions and immune responses. Understanding the expression and function of CEACAM5/6 is essential for developing targeted therapies and diagnostic tools in oncology, as elevated levels in tumor tissues compared to normal tissues can provide insights into tumor biology and patient prognosis. Anti-CEACAM5/6 antibody (By114) is an invaluable tool for researchers investigating cancer and other diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CEACAM5/6 Antibody (By114) References:
- Preclinical Activity of SAR408701: A Novel Anti-CEACAM5-maytansinoid Antibody-drug Conjugate for the Treatment of CEACAM5-positive Epithelial Tumors. | Decary, S., et al. 2020. Clin Cancer Res. 26: 6589-6599. PMID: 33046521
- Elevated CEACAM5 Levels in Patients with Asthma. | Xu, C., et al. 2022. Int Arch Allergy Immunol. 183: 673-681. PMID: 35172310
- CEACAM6 as a Novel Therapeutic Target to Boost HO-1-mediated Antioxidant Defense in COPD. | Wu, CY., et al. 2023. Am J Respir Crit Care Med. 207: 1576-1590. PMID: 37219322
- A novel human single-domain antibody-drug conjugate targeting CEACAM5 exhibits potent in vitro and in vivo antitumor activity. | Zhu, XY., et al. 2024. Acta Pharmacol Sin. 45: 609-618. PMID: 38030799
- Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers. | Seckinger, A., et al. 2023. J Hematol Oncol. 16: 117. PMID: 38087365
- CT109-SN-38, a Novel Antibody-drug Conjugate with Dual Specificity for CEACAM5 and 6, Elicits Potent Killing of Pancreatic Cancer Cells. | Cardenas, KCA., et al. 2024. Curr Cancer Drug Targets. 24: 720-732. PMID: 38178674
- CEACAM5 and TROP2 define metaplastic and dysplastic transitions in human antral gastric precancerous lesions and tumors. | Jang, B., et al. 2024. Gastric Cancer. 27: 263-274. PMID: 38221567
- Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance. | Michl, J., et al. 2024. Proc Natl Acad Sci U S A. 121: e2319055121. PMID: 38502695
- Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates. | Ajkunic, A., et al. 2024. NPJ Precis Oncol. 8: 104. PMID: 38760413
- CEACAM5-Targeted Immuno-PET in Androgen Receptor-Negative Prostate Cancer. | Imberti, C., et al. 2024. J Nucl Med. 65: 1043-1050. PMID: 38782457
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CEACAM5/6 Antibody (By114) | sc-20059 | 200 µg/ml | $322.00 | |||
CEACAM5/6 Antibody (By114): m-IgG Fc BP-HRP Bundle | sc-536649 | 200 µg Ab; 10 µg BP | $361.00 | |||
CEACAM5/6 Antibody (By114): m-IgGκ BP-HRP Bundle | sc-533807 | 200 µg Ab; 40 µg BP | $361.00 | |||
CEACAM5/6 Antibody (By114): m-IgG1 BP-HRP Bundle | sc-544733 | 200 µg Ab; 20 µg BP | $361.00 | |||
CEACAM5/6 Antibody (By114) FITC | sc-20059 FITC | 200 µg/ml | $336.00 | |||
CEACAM5/6 Antibody (By114) PE | sc-20059 PE | 200 µg/ml | $349.00 |