CDYL Antibody (E-8): sc-515793
- CDYL Antibody (E-8) is a mouse monoclonal IgG1 κ CDYL antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 96-121 near the N-terminus of CDYL of human origin
- CDYL Antibody (E-8) is recommended for detection of CDYL of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CDYL Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDYL Antibody (E-8) for WB applications. These reagents are now offered in bundles with CDYL Antibody (E-8) (see ordering information below).
QUICK LINKS
SEE ALSO...
CDYL Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CDYL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CDYL antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CDYL protein, part of a gene family expressed exclusively in the testis, is located on a region of the Y chromosome that is often deleted in cases of male infertility. CDYL features two functional domains: an N-terminal chromodomain that may play a role in heterochromatin interactions, and a C-terminal domain resembling enoyl-CoA isomerase, which is crucial for fatty acid oxidation. CDYL functions as a histone acetyltransferase with a strong preference for histone H4, a modification essential for the transition from histones to protamines during spermatogenesis, thereby linking CDYL to male fertility. CDYL is a ubiquitous nuclear protein expressed at moderate levels across various tissues, and the gene encoding CDYL is located on chromosome 6p25.1, highlighting CDYL′s potential significance in both reproductive biology and broader cellular functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CDYL Antibody (E-8) References:
- Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. | Lahn, BT. and Page, DC. 1999. Nat Genet. 21: 429-33. PMID: 10192397
- Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. | Lahn, BT., et al. 2002. Proc Natl Acad Sci U S A. 99: 8707-12. PMID: 12072557
- Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family. | Kostova, E., et al. 2002. Mol Hum Reprod. 8: 702-9. PMID: 12149400
- Comparative mapping of CDY and DAZ in higher primates. | Wimmer, R., et al. 2002. Cytogenet Genome Res. 96: 287-9. PMID: 12438810
- The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. | Dorus, S., et al. 2003. Hum Mol Genet. 12: 1643-50. PMID: 12837688
- Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis. | Kleiman, SE., et al. 2003. Hum Genet. 113: 486-92. PMID: 14569460
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDYL Antibody (E-8) | sc-515793 | 200 µg/ml | $322.00 | |||
CDYL Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-531515 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDYL Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-525219 | 200 µg Ab, 40 µg BP | $361.00 | |||
CDYL Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-544601 | 200 µg Ab; 20 µg BP | $361.00 | |||
CDYL Antibody (E-8) AC | sc-515793 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CDYL Antibody (E-8) HRP | sc-515793 HRP | 200 µg/ml | $322.00 | |||
CDYL Antibody (E-8) FITC | sc-515793 FITC | 200 µg/ml | $336.00 | |||
CDYL Antibody (E-8) PE | sc-515793 PE | 200 µg/ml | $349.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 488 | sc-515793 AF488 | 200 µg/ml | $364.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 546 | sc-515793 AF546 | 200 µg/ml | $364.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 594 | sc-515793 AF594 | 200 µg/ml | $364.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 647 | sc-515793 AF647 | 200 µg/ml | $364.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 680 | sc-515793 AF680 | 200 µg/ml | $364.00 | |||
CDYL Antibody (E-8) Alexa Fluor® 790 | sc-515793 AF790 | 200 µg/ml | $364.00 |