CDK5RAP3 Antibody (E-7): sc-271776

CDK5RAP3 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects CDK5RAP3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CDK5RAP3 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CDK5RAP3, also known as cyclin-dependent kinase 5 regulatory subunit-associated protein 3, C53, or IC53, plays a crucial role in neuronal differentiation, cell proliferation, and DNA repair, making CDK5RAP3 an important target for research in neurobiology and cancer. CDK5RAP3 is primarily located in the cytoplasm and interacts with the Cdk5 activator protein p35, which is essential for activating Cdk5′s enzymatic activity. This interaction is particularly significant during neuronal differentiation, as increased Cdk5 activity is observed at this stage. CDK5RAP3 functions as a regulatory component of the G2/M DNA damage checkpoint, responding to genotoxic stress, and is expressed in various tissues, including the brain, heart, placenta, liver, skeletal muscle, lung, kidney, and pancreas, with overexpression noted in tumor tissues. CDK5RAP3 exists in three named isoforms due to alternative splicing, and CDK5RAP3′s structure includes two leucine zipper motifs, potential phosphorylation sites, and possible N-myristoylation sites, all of which may influence functional interactions and regulatory mechanisms in cellular processes.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CDK5RAP3 Antibody (E-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CDK5RAP3 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CDK5RAP3 Antibody (E-7) Specifications

Alternate Product Name: CDK5RAP3

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 207-506

Epitope Target: CDK5RAP3

Epitope Species: human

Product Reactivity/Detection: CDK5RAP3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CDK5RAP3 Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred CDK5RAP3 antibody is CDK5RAP3 Antibody (B-11): sc-271671.