CDCP1 Antibody (D-1): sc-515545
- CDCP1 Antibody (D-1) is a mouse monoclonal IgG1 κ CDCP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 221-246 within an extracellular domain of CDCP1 isoform 1 of human origin
- CDCP1 Antibody (D-1) is recommended for detection of CDCP1 isoforms 1 and 2 of human origin by WB, IP, IF and ELISA
- Anti-CDCP1 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CDCP1 Antibody (D-1) for WB applications. These reagents are now offered in bundles with CDCP1 Antibody (D-1) (see ordering information below).
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CDCP1 Antibody (D-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects CDCP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CDCP1 Antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CDCP1, or CUB-domain-containing protein 1, plays a crucial role in cellular signaling and is involved in processes such as cell adhesion and migration, which are vital for tissue repair and cancer metastasis. CDCP1 is primarily located in the plasma membrane, where three extracellular CUB domains facilitate interactions with other proteins and extracellular matrix components, thereby influencing cellular behavior in response to environmental cues. CDCP1 is highly expressed in metastatic colon and breast tumors, making CDCP1 a significant marker for hematopoietic cells and a potential target for therapeutic interventions. Phosphorylation of CDCP1 by Src family kinases at specific tyrosine residues, including Tyr 734, enhances signaling capabilities, which can impact the progression of epithelial wounds and tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CDCP1 Antibody (D-1) References:
- Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. | Scherl-Mostageer, M., et al. 2001. Oncogene. 20: 4402-8. PMID: 11466621
- Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. | Hooper, JD., et al. 2003. Oncogene. 22: 1783-94. PMID: 12660814
- CDCP1 is a novel marker for hematopoietic stem cells. | Conze, T., et al. 2003. Ann N Y Acad Sci. 996: 222-6. PMID: 12799299
- Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. | Brown, TA., et al. 2004. J Biol Chem. 279: 14772-83. PMID: 14739293
- CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. | Bühring, HJ., et al. 2004. Stem Cells. 22: 334-43. PMID: 15153610
- The C2 domain of PKCdelta is a phosphotyrosine binding domain. | Benes, CH., et al. 2005. Cell. 121: 271-80. PMID: 15851033
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDCP1 Antibody (D-1) | sc-515545 | 200 µg/ml | $322.00 | |||
CDCP1 Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-531407 | 200 µg Ab; 10 µg BP | $361.00 | |||
CDCP1 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-525091 | 200 µg Ab, 40 µg BP | $361.00 | |||
CDCP1 Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-544534 | 200 µg Ab; 20 µg BP | $361.00 | |||
CDCP1 Antibody (D-1) AC | sc-515545 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CDCP1 Antibody (D-1) HRP | sc-515545 HRP | 200 µg/ml | $322.00 | |||
CDCP1 Antibody (D-1) FITC | sc-515545 FITC | 200 µg/ml | $336.00 | |||
CDCP1 Antibody (D-1) PE | sc-515545 PE | 200 µg/ml | $349.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 488 | sc-515545 AF488 | 200 µg/ml | $364.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 546 | sc-515545 AF546 | 200 µg/ml | $364.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 594 | sc-515545 AF594 | 200 µg/ml | $364.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 647 | sc-515545 AF647 | 200 µg/ml | $364.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 680 | sc-515545 AF680 | 200 µg/ml | $364.00 | |||
CDCP1 Antibody (D-1) Alexa Fluor® 790 | sc-515545 AF790 | 200 µg/ml | $364.00 | |||
CDCP1 (D-1) Neutralizing Peptide | sc-515545 P | 100 µg/0.5 ml | $69.00 |