CD98 Antibody (4F2): sc-59145
- CD98 Antibody (4F2) is a mouse monoclonal IgG2a κ, cited in 13 publications, provided at 200 µg/ml
- raised against the HOON pre-B leukemia cell line of human origin
- CD98 Antibody (4F2) is recommended for detection of CD98 of human origin by WB, IP, IF and FCM
- Anti-CD98 Antibody (4F2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD98 Antibody (4F2) for WB applications. These reagents are now offered in bundles with CD98 Antibody (4F2) (see ordering information below).
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CD98 Antibody (4F2) is a mouse monoclonal IgG2a kappa light chain antibody that detects CD98 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD98 antibody (4F2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD98, also known as SLC3A2, is a disulfide-linked heterodimer consisting of a glycosylated heavy chain and a non-glycosylated light chain, which plays a crucial role in cellular functions. CD98 is primarily located in the plasma membrane of various cell types, including T cells, monocytes, and to a lesser extent, granulocytes and platelets. CD98 functions as a scaffolding protein that interacts with basolaterally expressed amino acid transporters and β1 integrins, thereby influencing amino acid transport, cell adhesion, migration, and branching morphogenesis. CD98 is upregulated upon T cell activation, suggesting involvement in the regulation of T cell activation and proliferation. Alternate transcriptional splice variants exist for the human CD98 gene, encoding different isoforms that may have distinct functional roles.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD98 Antibody (4F2) References:
- Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth. | Rintoul, RC., et al. 2002. Mol Biol Cell. 13: 2841-52. PMID: 12181350
- CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia. | Liu, X., et al. 2003. J Biol Chem. 278: 23672-7. PMID: 12716892
- The targeted disruption of the CD98 gene results in embryonic lethality. | Tsumura, H., et al. 2003. Biochem Biophys Res Commun. 308: 847-51. PMID: 12927796
- CD98 modulates integrin beta1 function in polarized epithelial cells. | Cai, S., et al. 2005. J Cell Sci. 118: 889-99. PMID: 15713750
- Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. | Gottesdiener, KM., et al. 1988. Mol Cell Biol. 8: 3809-19. PMID: 3265470
- Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth. | Quackenbush, E., et al. 1987. Proc Natl Acad Sci U S A. 84: 6526-30. PMID: 3476959
- Cloning, sequence analysis, and expression of the large subunit of the human lymphocyte activation antigen 4F2. | Lumadue, JA., et al. 1987. Proc Natl Acad Sci U S A. 84: 9204-8. PMID: 3480538
- Galectin-3 enhances atrial remodelling and arrhythmogenesis through CD98 signalling. | Cheng, WL., et al. 2022. Acta Physiol (Oxf). 234: e13784. PMID: 34995420
- N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98). | Console, L., et al. 2022. Sci Rep. 12: 14570. PMID: 36028562
- CD98 expression can be a predictive factor of resistance to radiotherapy in head and neck squamous cell carcinoma. | Suzuki, H., et al. 2023. Pol J Pathol. 74: 122-130. PMID: 37728471
- CD98: a type II transmembrane glycoprotein expressed from the beginning of primitive and definitive hematopoiesis may play a critical role in the development of hematopoietic cells. | Warren, AP., et al. 1996. Blood. 87: 3676-87. PMID: 8611692
- Monocyte-dependent regulation of T lymphocyte activation through CD98. | Diaz, LA., et al. 1997. Int Immunol. 9: 1221-31. PMID: 9310825
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD98 Antibody (4F2) | sc-59145 | 200 µg/ml | $322.00 | |||
CD98 Antibody (4F2): m-IgG Fc BP-HRP Bundle | sc-528634 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD98 Antibody (4F2): m-IgGκ BP-HRP Bundle | sc-521064 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD98 Antibody (4F2) AC | sc-59145 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD98 Antibody (4F2) HRP | sc-59145 HRP | 200 µg/ml | $322.00 | |||
CD98 Antibody (4F2) FITC | sc-59145 FITC | 200 µg/ml | $336.00 | |||
CD98 Antibody (4F2) PE | sc-59145 PE | 200 µg/ml | $349.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 488 | sc-59145 AF488 | 200 µg/ml | $364.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 546 | sc-59145 AF546 | 200 µg/ml | $364.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 594 | sc-59145 AF594 | 200 µg/ml | $364.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 647 | sc-59145 AF647 | 200 µg/ml | $364.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 680 | sc-59145 AF680 | 200 µg/ml | $364.00 | |||
CD98 Antibody (4F2) Alexa Fluor® 790 | sc-59145 AF790 | 200 µg/ml | $364.00 |