CD94 Antibody (H-3): sc-390776

CD94 Antibody (H-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects CD94 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD94 (H-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD94 plays a crucial role in the immune response, particularly in the regulation of natural killer (NK) cell activity. CD94 is a member of the C-type lectin superfamily and is primarily located on the surface of NK cells, where CD94 forms heterodimers with NKG2 isoforms. This interaction is vital for the recognition of class I major histocompatibility complex (MHC) molecules, which helps to distinguish between healthy and stressed or infected cells. The ability of CD94 to form these heterodimers enhances NK cell′s ability to respond to tumor cells and virally infected cells, making CD94 an important target for therapeutic interventions in cancer and infectious diseases. Using anti-CD94 antibody (H-3) in research can provide insights into the mechanisms of immune regulation and the potential for developing novel immunotherapies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD94 Antibody (H-3) References:

1. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.  |  Bauer, S., et al. 1999. Science. 285: 727-9. PMID: 10426993
2. Inhibitory role of murine Ly49 lectin-like receptors on natural killer cells.  |  Salcedo, M. 1999. Curr Top Microbiol Immunol. 244: 97-105. PMID: 10453652
3. Molecular cloning of a novel murine cell-surface glycoprotein homologous to killer cell inhibitory receptors.  |  Hayami, K., et al. 1997. J Biol Chem. 272: 7320-7. PMID: 9054430
4. Divergent functions of lectin-like receptors on NK cells.  |  Ryan, JC. and Seaman, WE. 1997. Immunol Rev. 155: 79-89. PMID: 9059884
5. Natural killer cell receptors.  |  Long, EO. and Wagtmann, N. 1997. Curr Opin Immunol. 9: 344-50. PMID: 9203417
6. HLA class I specific inhibitory receptors.  |  Moretta, A. and Moretta, L. 1997. Curr Opin Immunol. 9: 694-701. PMID: 9368779
7. Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells.  |  Vance, RE., et al. 1997. Eur J Immunol. 27: 3236-41. PMID: 9464811
8. The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrate.  |  Berg, KL., et al. 1998. Oncogene. 17: 2535-41. PMID: 9824165

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD94 Antibody (H-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD94 Antibody (H-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD94 Antibody (H-3) Specifications

Alternate Product Name: CD94

Product Clone Name: H-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 111-179

Epitope Target: CD94

Epitope Species: human

Product Reactivity/Detection: CD94

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD94 Antibody (H-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin