CD88 Antibody (P12/1): sc-53794

CD88 Antibody (P12/1) is a mouse monoclonal IgG2a antibody that detects CD88 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD88, also known as the C5a receptor (C5aR), is a G protein-coupled integral membrane protein predominantly expressed on immune cells including neutrophils, monocytes, macrophages, and mast cells, as well as on various epithelial and endothelial cells. Anti-CD88 antibody (P12/1) recognizes a receptor that plays a crucial role in mediating the inflammatory response by binding to the inflammatory peptide C5a, which triggers a cascade of cellular events leading to the production of acute phase proteins in the liver. CD88′s significance extends to its involvement in various pathological conditions; for instance, elevated levels of CD88 in the brain have been linked to neuroinflammation, while its interaction with C5a is implicated in the pathogenesis of rheumatoid arthritis. Furthermore, research indicates that human bronchial epithelial cells exhibit heightened sensitivity to C5a following exposure to environmental irritants such as cigarette smoke, underscoring CD88′s importance in both innate immunity and chronic inflammatory diseases. CD88 (P12/1) antibody serves as an essential tool for researchers aiming to explore the multifaceted roles of this receptor in health and disease.

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CD88 Antibody (P12/1) References:

1. Human complement 5a (C5a) anaphylatoxin receptor (CD88) phosphorylation sites and their specific role in receptor phosphorylation and attenuation of G protein-mediated responses. Desensitization of C5a receptor controls superoxide production but not receptor sequestration in HL-60 cells.  |  Christophe, T., et al. 2000. J Biol Chem. 275: 1656-64. PMID: 10636859
2. Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis.  |  Furebring, M., et al. 2002. Crit Care. 6: 363-70. PMID: 12225614
3. The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres.  |  Crane, JW., et al. 2009. J Neuroinflammation. 6: 34. PMID: 19917081
4. Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease.  |  Ager, RR., et al. 2010. J Neurochem. 113: 389-401. PMID: 20132482
5. Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology.  |  Fonseca, MI., et al. 2013. J Neuroinflammation. 10: 25. PMID: 23394121
6. C5a receptor (CD88) blockade protects against MPO-ANCA GN.  |  Xiao, H., et al. 2014. J Am Soc Nephrol. 25: 225-31. PMID: 24179165
7. CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity.  |  Manouchehri, N., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 33785592
8. The Platelet Anaphylatoxin Receptor C5aR1 (CD88) Is a Promising Target for Modulating Vessel Growth in Response to Ischemia a.  |  Nording, H., et al. 2023. TH Open. 7: e289-e293. PMID: 37868192
9. Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells.  |  Füreder, W., et al. 1995. J Immunol. 155: 3152-60. PMID: 7673728
10. Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis.  |  Kiener, HP., et al. 1998. Arthritis Rheum. 41: 233-45. PMID: 9485081

The preferred CD88 antibody is CD88 Antibody (B-6): sc-271949.