CD84 Antibody (2Q1463): sc-70810

CD84 Antibody (2Q1463) is a mouse monoclonal IgG1 antibody that detects CD84 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD84 is a member of the immunoglobulin superfamily and plays a crucial role in immune responses, particularly in the activation and regulation of B lymphocytes, monocytes, and platelets. CD84 is primarily located on the surface of these immune cells, where CD84 functions as a costimulatory molecule, enhancing the activation signals received during immune responses. This localization is vital as CD84 interacts with its ligands, facilitating communication between immune cells and promoting effective immune activation. Notably, CD84 exists in five isoforms—CD84a, CD84b, CD84c, CD84d, and CD84e—each exhibiting distinct expression patterns and regulatory mechanisms, which may include differential phosphorylation sites that modulate their activity in signal transduction pathways. CD84′s ability to act as its own ligand underscores CD84′s importance in immune cell signaling and the overall orchestration of immune responses, making anti-CD84 antibody (2Q1463) an essential tool for researchers studying immune function and related disorders.

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CD84 Antibody (2Q1463) References:

1. Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84.  |  Doherty, TA., et al. 2014. J Allergy Clin Immunol. 133: 1203-5. PMID: 24582313
2. CD84 mediates CLL-microenvironment interactions.  |  Marom, A., et al. 2017. Oncogene. 36: 628-638. PMID: 27452524
3. CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders.  |  Cuenca, M., et al. 2019. Clin Immunol. 204: 43-49. PMID: 30522694
4. Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner.  |  Barak, AF., et al. 2020. Oncogene. 39: 1997-2008. PMID: 31772329
5. CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.  |  Lewinsky, H., et al. 2021. JCI Insight. 6: PMID: 33465053
6. CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis.  |  Zheng, N., et al. 2022. Microbiol Spectr. 10: e0155721. PMID: 35196822
7. Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors.  |  Pettinella, F., et al. 2024. Cell Rep Med. 5: 101380. PMID: 38242120
8. Terminal deoxynucleotidyl transferase and CD84 identify human multi-potent lymphoid progenitors.  |  Kim, Y., et al. 2024. Nat Commun. 15: 5910. PMID: 39003273
9. In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.  |  Nagesh, PT., et al. 2024. Sci Transl Med. 16: eadg1915. PMID: 39110779
10. CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer.  |  Rabani, S., et al. 2024. Cell Rep. 43: 114920. PMID: 39466774

The preferred CD84 antibody is CD84 Antibody (152-1D5): sc-23899.