CD84 Antibody (152-1D5): sc-23899

CD84 Antibody (152-1D5) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD84 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD84 (152-1D5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD84 plays a crucial role in immune regulation, particularly in the activation and differentiation of B lymphocytes, monocytes, and platelets, where CD84 functions as a costimulatory molecule. Located on the cell surface, CD84 interacts with other members of the immunoglobulin superfamily, such as CD2, CD48, and CD58, facilitating important signaling pathways that enhance immune responses. The human CD84 gene is situated on chromosome 1q24 and consists of at least eight exons, which encode various structural components, including two extracellular immunoglobulin-like domains, a hydrophobic transmembrane region, and cytoplasmic domains. Notably, five isoforms of CD84 have been identified, each exhibiting distinct expression patterns and potential phosphorylation sites that may regulate their activity in signal transduction. The ability of CD84 to act as its own ligand underscores its significance in modulating immune cell interactions and responses, making anti-CD84 antibody (152-1D5) an essential tool for researchers studying immune mechanisms and cellular communication.

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CD84 Antibody (152-1D5) References:

1. Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains.  |  Palou, E., et al. 2000. Tissue Antigens. 55: 118-27. PMID: 10746783
2. CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.  |  Martin, M., et al. 2001. J Immunol. 167: 3668-76. PMID: 11564780
3. CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders.  |  Cuenca, M., et al. 2019. Clin Immunol. 204: 43-49. PMID: 30522694
4. CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.  |  Schuhmann, MK., et al. 2020. Circ Res. 127: 1023-1035. PMID: 32762491
5. CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.  |  Lewinsky, H., et al. 2021. JCI Insight. 6: PMID: 33465053
6. CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis.  |  Zheng, N., et al. 2022. Microbiol Spectr. 10: e0155721. PMID: 35196822
7. Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors.  |  Pettinella, F., et al. 2024. Cell Rep Med. 5: 101380. PMID: 38242120
8. Terminal deoxynucleotidyl transferase and CD84 identify human multi-potent lymphoid progenitors.  |  Kim, Y., et al. 2024. Nat Commun. 15: 5910. PMID: 39003273
9. In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.  |  Nagesh, PT., et al. 2024. Sci Transl Med. 16: eadg1915. PMID: 39110779
10. CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway.  |  Song, Y., et al. 2024. Oncogene. 43: 2737-2749. PMID: 39112517
11. CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer.  |  Rabani, S., et al. 2024. Cell Rep. 43: 114920. PMID: 39466774
12. CD84 leukocyte antigen is a new member of the Ig superfamily.  |  de la Fuente, MA., et al. 1997. Blood. 90: 2398-405. PMID: 9310491

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD84 Antibody (152-1D5) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-CD84 Antibody (152-1D5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD84 Antibody (152-1D5) Specifications

Alternate Product Name: CD84

Product Clone Name: 152-1D5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CD84

Epitope Species: human

Product Reactivity/Detection: CD84

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for CD84 Antibody (152-1D5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin