CD84 Antibody (0.N.167): sc-70809

CD84 Antibody (0.N.167) is a mouse monoclonal IgG1 antibody that detects CD84 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD84 is a member of the immunoglobulin superfamily and plays a crucial role in immune responses by acting as a costimulatory molecule on B lymphocytes, monocytes, and platelets. Anti-CD84 antibody (0.N.167) recognizes CD84 primarily on the surface of immune cells, where CD84 facilitates cell signaling and enhances T cell activation, contributing to the overall immune response. CD84′s presence on these cells is vital for effective immune function, as CD84 helps modulate interactions between immune cells and influences immune response outcomes. Notably, CD84 exists in five isoforms—CD84a, CD84b, CD84c, CD84d, and CD84e—each generated through alternative splicing and exhibiting differential expression patterns. These isoforms may have distinct roles in immune signaling, and their regulation through post-translational modifications, such as phosphorylation, can further fine-tune their activity. CD84 (0.N.167) antibody serves as an essential tool for researchers studying immune cell interactions and mechanisms underlying immune regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD84 Antibody (0.N.167) References:

1. Molecular cloning, characterization, and chromosomal localization of the mouse homologue of CD84, a member of the CD2 family of cell surface molecules.  |  de la Fuente, MA., et al. 1999. Immunogenetics. 49: 249-55. PMID: 10079287
2. Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains.  |  Palou, E., et al. 2000. Tissue Antigens. 55: 118-27. PMID: 10746783
3. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue.  |  Zhang, W., et al. 2001. Clin Cancer Res. 7: 822s-829s. PMID: 11300479
4. Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.  |  Sayós, J., et al. 2001. Blood. 97: 3867-74. PMID: 11389028
5. Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation.  |  Tangye, SG., et al. 2003. J Immunol. 171: 2485-95. PMID: 12928397
6. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4).  |  Romero, X., et al. 2004. Tissue Antigens. 64: 132-44. PMID: 15245368
7. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.  |  Cui, J., et al. 2013. PLoS Genet. 9: e1003394. PMID: 23555300
8. Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis.  |  van den Reek, JMPA., et al. 2017. Br J Dermatol. 176: 1288-1296. PMID: 27564082
9. Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane.  |  Wang, TTY., et al. 2018. Int J Mol Sci. 19: PMID: 29364159
10. CD84 leukocyte antigen is a new member of the Ig superfamily.  |  de la Fuente, MA., et al. 1997. Blood. 90: 2398-405. PMID: 9310491

The preferred CD84 antibody is CD84 Antibody (152-1D5): sc-23899.