CD83 Antibody (HB15E): sc-19678
- CD83 Antibody (HB15E) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against COS cells transfected with human CD83
- recommended for detection of CD83 of human origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See CD83 (D-3): sc-55536 for CD83 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD83 Antibody (HB15E). These reagents are now offered in bundles with CD83 Antibody (HB15E) (see ordering information below).
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CD83 Antibody (HB15E) is a mouse monoclonal IgG1 antibody that detects CD83 in human samples through immunofluorescence (IF) and flow cytometry (FCM). Anti-CD83 antibody (HB15E) recognizes a heavily glycosylated membrane protein belonging to the immunoglobulin superfamily, which plays a crucial role in the immune response by marking mature dendritic cells, Langerhans cells, and interdigitating reticulum cells within lymphoid tissues. CD83 (HB15E) antibody recognizes a structure including an extracellular V-type immunoglobulin-like domain, a single transmembrane domain, and a 40-residue cytoplasmic tail, which are essential for cell adhesion and signaling. CD83 monoclonal antibody (HB15E) targets a protein involved in the interactions between dendritic cells and monocytes as well as CD8+ T cells, facilitating the generation of tumor-specific T cell immunity, a critical aspect for developing effective anti-cancer vaccines. Studies involving CD83-IgG1(fc) chimeras have revealed that CD83 functions as a sialic acid-binding Ig-like lectin (Siglec) adhesion molecule, further underscoring its importance in immune cell communication and the overall immune response.
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CD83 Antibody (HB15E) References:
- Role of CD83 in the immunomodulation of dendritic cells. | Lechmann, M., et al. 2002. Int Arch Allergy Immunol. 129: 113-8. PMID: 12403928
- CD83: a regulatory molecule of the immune system with great potential for therapeutic application. | Fujimoto, Y. and Tedder, TF. 2006. J Med Dent Sci. 53: 85-91. PMID: 16913569
- CD83 regulates lymphocyte maturation, activation and homeostasis. | Breloer, M. and Fleischer, B. 2008. Trends Immunol. 29: 186-94. PMID: 18329338
- CD83 and GRASP55 interact in human dendritic cells. | Stein, MF., et al. 2015. Biochem Biophys Res Commun. 459: 42-8. PMID: 25701785
- CD83 orchestrates immunity toward self and non-self in dendritic cells. | Wild, AB., et al. 2019. JCI Insight. 4: PMID: 31527313
- Endogenous CD83 Expression in CD4+ Conventional T Cells Controls Inflammatory Immune Responses. | Liedtke, K., et al. 2020. J Immunol. 204: 3217-3226. PMID: 32341061
- Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation. | Peckert-Maier, K., et al. 2022. Int J Mol Sci. 23: PMID: 35054916
- A sustained decrease in serum CD83 in pregnant women. | Vinketova, K., et al. 2022. J Reprod Immunol. 154: 103762. PMID: 36401917
- CD83 expressed by macrophages is an important immune checkpoint molecule for the resolution of inflammation. | Peckert-Maier, K., et al. 2023. Front Immunol. 14: 1085742. PMID: 36875129
- γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. | León-Lara, X., et al. 2024. J Exp Med. 221: PMID: 38753245
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD83 Antibody (HB15E) | sc-19678 | 200 µg/ml | $316.00 | |||
CD83 Antibody (HB15E): m-IgG Fc BP-HRP Bundle | sc-536632 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD83 Antibody (HB15E): m-IgGκ BP-HRP Bundle | sc-533789 | 200 µg Ab; 40 µg BP | $354.00 | |||
CD83 Antibody (HB15E): m-IgG1 BP-HRP Bundle | sc-544719 | 200 µg Ab; 20 µg BP | $354.00 | |||
CD83 Antibody (HB15E) FITC | sc-19678 FITC | 200 µg/ml | $330.00 | |||
CD83 Antibody (HB15E) PE | sc-19678 PE | 200 µg/ml | $343.00 |