CD81 Antibody (0.N.165): sc-70803

CD81 Antibody (0.N.165) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target CD81, also known as TAPA-1, a pivotal member of the tetraspanin family. CD81 is a type III transmembrane protein widely expressed on cells of hematopoietic, neuroectodermal, and mesenchymal origin, where CD81 plays essential roles in cell growth and signal transduction. CD81 is integral to the formation of multimolecular complexes, interacting with key proteins such as CD19, CD21, CD37, CD53, and MHC class II antigens, which are crucial for immune cell function and communication. Developed using a human B cell line from Burkitt lymphoma, anti-CD81 antibody (0.N.165) detects CD81 in mouse, rat, and human species through applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD81 monoclonal antibody (0.N.165) enables researchers to investigate the interactions between CD81 and its partner proteins, providing insights into mechanisms underlying immune responses, B cell receptor signaling, and cellular adhesion processes. The interactions with CD19 and CD21 are particularly important for B cell activation and antibody production, while associations with CD37 and CD53 regulate various cellular signaling pathways. CD81′s interaction with MHC class II antigens plays a critical role in antigen presentation and immune surveillance. Available in both conjugated and non-conjugated forms, CD81 (0.N.165) antibody offers versatile options for diverse experimental needs, making CD81 (0.N.165) monoclonal antibody an invaluable tool for studies in immunology, cell biology, and therapeutic development.

The preferred CD81 antibody is CD81 Antibody (1.3.3.22): sc-7637.