CD8 Antibody (2.43): sc-18860
- CD8 Antibody (2.43) is a rat monoclonal IgG2b, cited in 14 publications, provided at 200 µg/ml
- raised against CTL clone L3 cells of mouse origin
- recommended for detection of CD8 of mouse origin by IF and FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- See CD8 (32-M4): sc-1177 for CD8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD8 Antibody (2.43). This work is in progress.
CD8 Antibody (2.43) is a rat monoclonal IgG2b antibody that detects CD8 in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. CD8 is a crucial cell surface glycoprotein that forms a heterodimer, typically existing as either an αα or αβ chain complex, and plays a vital role in the immune response by binding to class I major histocompatibility complex (MHC) molecules presented by antigen-presenting cells. This interaction is essential for T cytotoxic cells, which express CD8, as CD8 enhances the recognition of antigens by the T cell receptor (TCR), thereby strengthening the immune response against infected or malignant cells. Additionally, CD8-expressing T cells are implicated in maintaining low levels of HIV expression, highlighting their importance not only in direct cytotoxicity but also in regulating viral load. The ability of CD8 to facilitate antigen recognition and enhance TCR avidity underscores CD8′s significance in adaptive immunity, making anti-CD8 antibody (2.43) an invaluable tool for researchers studying T cell dynamics and immune responses in mouse models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD8 Antibody (2.43) References:
- Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion. | Yu, YR., et al. 2020. Nat Immunol. 21: 1540-1551. PMID: 33020660
- Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma. | Oliveira, G., et al. 2021. Nature. 596: 119-125. PMID: 34290406
- The CD8α-PILRα interaction maintains CD8+ T cell quiescence. | Zheng, L., et al. 2022. Science. 376: 996-1001. PMID: 35617401
- Carbon source availability drives nutrient utilization in CD8+ T cells. | Kaymak, I., et al. 2022. Cell Metab. 34: 1298-1311.e6. PMID: 35981545
- Tumor immunogenicity dictates reliance on TCF1 in CD8+ T cells for response to immunotherapy. | Escobar, G., et al. 2023. Cancer Cell. 41: 1662-1679.e7. PMID: 37625402
- HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity. | Migueles, SA., et al. 2023. Science. 382: 1270-1276. PMID: 38096385
- Immunometabolism of CD8+ T cell differentiation in cancer. | Shi, H., et al. 2024. Trends Cancer. 10: 610-626. PMID: 38693002
- DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism. | Li, S., et al. 2024. Cell Discov. 10: 53. PMID: 38763950
- IL-4 drives exhaustion of CD8+ CART cells. | Stewart, CM., et al. 2024. Nat Commun. 15: 7921. PMID: 39266501
- Histone lactylation drives CD8+ T cell metabolism and function. | Raychaudhuri, D., et al. 2024. Nat Immunol. 25: 2140-2151. PMID: 39375549
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD8 Antibody (2.43) | sc-18860 | 200 µg/ml | $316.00 | |||
CD8 Antibody (2.43) Alexa Fluor® 488 | sc-18860 AF488 | 200 µg/ml | $357.00 | |||
CD8 Antibody (2.43) Alexa Fluor® 647 | sc-18860 AF647 | 200 µg/ml | $357.00 | |||
CD8 Antibody (2.43) FITC | sc-18860 FITC | 200 µg/ml | $330.00 | |||
CD8 Antibody (2.43) PE | sc-18860 PE | 200 µg/ml | $343.00 |