CD8-alpha Antibody (6A242): sc-70802
- CD8-α Antibody (6A242) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against thymocyte membrane glycoproteins of rat origin
- recommended for detection of CD8-α of mouse and rat origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for blocking, sc-70802 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD8-α Antibody (6A242) for WB and IHC(P) applications. These reagents are now offered in bundles with CD8-α Antibody (6A242) (see ordering information below).
CD8-α Antibody (6A242) is a mouse monoclonal IgG1 kappa light chain antibody raised against thymocyte membrane glycoproteins of rat origin, designed for the detection of CD8-α in mouse and rat samples via western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD8-α, also known as CD8A, Leu2, or p32, is a cell surface glycoprotein predominantly expressed on cytotoxic T lymphocytes and some natural killer cells, forming either homodimers (αα) or heterodimers (αβ) with CD8-β. CD8-α plays a crucial role in the immune system by binding to major histocompatibility complex (MHC) class I molecules on antigen-presenting cells, thereby enhancing antigen recognition by the T cell receptor (TCR) and strengthening T cell-antigen presenting cell interactions. This function is essential for the activation and cytotoxic response of CD8+ T cells against intracellular pathogens and tumor cells. CD8-α is vital for T cell development, selection, and peripheral immune responses, making CD8-α a significant marker in immunological research and diagnostics. Anti-CD8-α antibody (6A242) is a valuable tool for studying T cell-mediated immunity and for the identification and characterization of CD8+ T cell populations in various biological samples.
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CD8-alpha Antibody (6A242) References:
- Familial CD8 deficiency due to a mutation in the CD8 alpha gene. | de la Calle-Martin, O., et al. 2001. J Clin Invest. 108: 117-23. PMID: 11435463
- CD3 delta establishes a functional link between the T cell receptor and CD8. | Doucey, MA., et al. 2003. J Biol Chem. 278: 3257-64. PMID: 12215456
- Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung. | Hammad, H., et al. 2004. Clin Exp Allergy. 34: 1834-40. PMID: 15663556
- Epitope-specific binding of CD8 regulates activation of T cells and induction of cytotoxicity. | Tomonari, K. and Spencer, S. 1990. Int Immunol. 2: 1189-94. PMID: 1708676
- CD8+ alpha/beta or gamma/delta T cell receptor-bearing T cells from athymic nude mice are cytolytically active in vivo. | Lake, JP., et al. 1991. J Immunol. 147: 1121-6. PMID: 1831217
- Lymphocyte differentiation in sea bass thymus: CD4 and CD8-alpha gene expression studies. | Picchietti, S., et al. 2009. Fish Shellfish Immunol. 27: 50-6. PMID: 19422917
- Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency. | Roifman, CM., et al. 1989. J Exp Med. 170: 2177-82. PMID: 2511270
- Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. | Sad, S., et al. 1995. Immunity. 2: 271-9. PMID: 7697544
- High frequency of CD8 alpha alpha homodimer-bearing T cells in human fetal intestine. | Latthe, M., et al. 1994. Eur J Immunol. 24: 1703-5. PMID: 8026531
- Early stages in the development of human T, natural killer and thymic dendritic cells. | Spits, H., et al. 1998. Immunol Rev. 165: 75-86. PMID: 9850853
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD8-α Antibody (6A242) | sc-70802 | 200 µg/ml | $322.00 | |||
CD8-α Antibody (6A242): m-IgG Fc BP-HRP Bundle | sc-539312 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD8-α Antibody (6A242): m-IgG1 BP-HRP Bundle | sc-541401 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD8-α Antibody (6A242) FITC | sc-70802 FITC | 200 µg/ml | $336.00 | |||
CD8-α Antibody (6A242) L | sc-70802 L | 200 µg/0.1 ml | $322.00 | |||
CD8-α Antibody (6A242) PE | sc-70802 PE | 200 µg/ml | $349.00 |