CD79B Antibody (B29/123): sc-53210

CD79B Antibody (B29/123) is a mouse monoclonal IgG2b λ light chain antibody that detects CD79B protein of mouse, rat, human, porcine, and equine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CD79B antibody (B29/123) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD79B protein, also known as Ig β, plays a crucial role in forming B cell antigen receptor complex by associating with CD79A (Ig α) and membrane immunoglobulin, such as IgM or IgD. This interaction is vital for proper surface expression of immunoglobulins, which are essential for effective antigen presentation and subsequent B cell activation. CD79B′s cytoplasmic tail contains an immuno-receptor tyrosine-based activation motif (ITAM) that is critical for initiating B cell receptor signaling by recruiting and activating tyrosine kinases, thereby triggering downstream signaling pathways that lead to B cell proliferation and differentiation. Understanding CD79B′s function is important for elucidating mechanisms of B cell activation and immune response, making CD79B (B29/123) monoclonal antibody a valuable tool for researchers studying immunology and related fields.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD79B Antibody (B29/123) References:

1. The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation.  |  Mason, DY., et al. 1992. Eur J Immunol. 22: 2753-6. PMID: 1396979
2. Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene.  |  Ha, HJ., et al. 1992. J Immunol. 148: 1526-31. PMID: 1538135
3. The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.  |  Mason, DY., et al. 1991. J Immunol. 147: 2474-82. PMID: 1747162
4. The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.  |  van Noesel, CJ., et al. 1991. J Immunol. 146: 3881-8. PMID: 2033258
5. CD79B limits response of diffuse large B cell lymphoma to ibrutinib.  |  Kim, JH., et al. 2016. Leuk Lymphoma. 57: 1413-22. PMID: 26699656
6. Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections.  |  Poppema, S., et al. 1987. Am J Pathol. 127: 418-29. PMID: 3296769
7. A novel ten-gene prognostic signature for cervical cancer based on CD79B-related immunomodulators.  |  Pu, D., et al. 2022. Front Genet. 13: 933798. PMID: 36406115
8. CD79B Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma.  |  Yamaguchi, J., et al. 2023. Cancer Med. 12: 7116-7126. PMID: 36478416
9. CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples.  |  Mason, DY., et al. 1995. Blood. 86: 1453-9. PMID: 7632952
10. Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB).  |  Wood, WJ., et al. 1993. Genomics. 16: 187-92. PMID: 8486355
11. Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.  |  Jones, M., et al. 1993. J Immunol. 150: 5429-35. PMID: 8515069
12. The antigen receptor complex on cord B lymphocytes.  |  Macardle, PJ., et al. 1997. Immunology. 90: 376-82. PMID: 9155644

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD79B Antibody (B29/123) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-CD79B Antibody (B29/123) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD79B Antibody (B29/123) Specifications

Alternate Product Name: CD79B

Product Clone Name: B29/123

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b lambda light chain

Amino Acids:

Epitope Target: CD79B

Epitope Species: mouse

Product Reactivity/Detection: CD79B

Species Reactivity/Detection: mouse, rat, human, porcine, equine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for CD79B Antibody (B29/123): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin