CD74 Antibody (M-B741): sc-65272

CD74 Antibody (M-B741) is a mouse monoclonal IgG2a antibody that detects CD74 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules. This process is vital for the proper presentation of antigens to T lymphocytes, which is essential for initiating adaptive immune responses. CD74 is predominantly expressed in B lymphocytes and is also found in a subset of T lymphocytes, highlighting CD74′s importance in both humoral and cellular immunity. The interaction of CD74 with MHC II during transport to the endosomal compartment ensures that only properly processed peptides are presented to T cells, thereby influencing the activation and differentiation of these immune cells. CD74′s ability to modulate MHC II function underscores CD74′s significance in immune regulation and potential implications in autoimmune diseases and immunotherapy. Anti-CD74 antibody (M-B741) is an invaluable tool for researchers studying immune responses and the mechanisms of antigen presentation.

The preferred CD74 antibody is CD74 Antibody (LN-2): sc-6262.