Date published: 2026-4-29

1-800-457-3801

SCBT Portrait Logo
Seach Input

CD74 Antibody (2X31): sc-70781

3.0(2)
Write a reviewAsk a question

Datasheets
  • CD74 Antibody (2X31) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
  • raised against SU-DHL-4 lymphoma cells
  • recommended for detection of CD74 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
  • See CD74 (LN-2): sc-6262 for CD74 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD74 Antibody (2X31) for WB and IHC(P) applications. These reagents are now offered in bundles with CD74 Antibody (2X31) (see ordering information below).
Gene Editing Promo Banner

QUICK LINKS

SEE ALSO...

CD74 Antibody (2X31) is a mouse monoclonal IgG1 antibody that recognizes CD74 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating peptide loading onto major histocompatibility complex class II (MHC II) molecules. This process is vital for proper antigen presentation to T lymphocytes, which is essential for initiating adaptive immune responses. The interaction between CD74 and MHC II occurs during MHC II transport to the endosomal compartment, where peptide binding takes place. CD74 is expressed in various immune cells, particularly in normal B lymphocytes, and CD74 expression is critical for the development and function of these cells. CD74 involvement in immune signaling pathways highlights CD74 importance in maintaining immune homeostasis and responding to pathogens. Anti-CD74 antibody (2X31) serves as an invaluable tool for researchers studying immune responses, antigen presentation, and related cellular processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CD74 Antibody (2X31)

sc-70781
200 µg/ml
$322.00

CD74 Antibody (2X31): m-IgG Fc BP-HRP Bundle

sc-539310
200 µg Ab; 10 µg BP
$361.00

CD74 Antibody (2X31): m-IgG1 BP-HRP Bundle

sc-541399
200 µg Ab; 20 µg BP
$361.00

May I know which site/ epitope of CD74 that CD74 (2X31): sc70781 recognises/ binds? I am curious about whether this antibody can detect all forms of CD74 (as I created various CD74 mutants).

Asked by: Lynn93
Thank you for the question. This CD74 specific antibody was raised against SU-DHL-4 lymphoma cells. The exact binding epitope has not been determined exactly, yet. If you are working with CD74 mutants you might also want to check other available CD74 antibodies. We offer two antibodies raised against specific peptides/ rec. protein fragments: sc-47742 was raised against aas 12-28 (h) sc-166047 was raised against aas 7-296 (h) https://www.scbt.com/scbt/browse/cd74-Antik%C3%B6rper/_/N-6thh37
Answered by: Technical Support Europe
Date published: 2018-01-11

Can CD74 (2X31): sc-70781 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, CD74 (2X31): sc-70781 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
  • y_2026, m_4, d_25, h_11CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_70781, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 112ms
  • QUESTIONS, PRODUCT
Rated 3 out of 5 by from Robust bands seen in WB using NAMALWARobust bands seen in WB using NAMALWA, IB4, J774.A1 and BJAB whole cell lysates. -SCBT QC
Date published: 2015-05-24
Rated 3 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2013-06-01
  • y_2026, m_4, d_25, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_70781, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
CD74 Antibody (2X31) is rated 3.0 out of 5 by 2.
  • y_2026, m_4, d_25, h_11
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_70781, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 113ms
  • REVIEWS, PRODUCT