CD72 Antibody (Bu40): sc-80734
- CD72 Antibody (Bu40) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against HFB1 plasmacytoid cell line of human origin
- recommended for detection of CD72 of human origin by IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CD72 Antibody (Bu40) for IHC(P) applications. These reagents are now offered in bundles with CD72 Antibody (Bu40) (see ordering information below).
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CD72 Antibody (Bu40) is a mouse monoclonal IgG2a antibody that detects CD72 in human samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD72 is a crucial transmembrane glycoprotein that plays a significant role in the regulation of B cell activation, acting as a negative regulator from the pro-B cell stage through to mature B cells. The importance of CD72 lies in its ability to modulate immune responses; CD72 contains an immunoreceptor tyrosine-based inhibition motif (ITIM) that, upon tyrosine phosphorylation, recruits SH2-containing phosphatases like SHP-1, leading to the downregulation of cell activation. This regulatory mechanism is vital for maintaining immune homeostasis, as evidenced by the hyperproliferative B cells observed in CD72-deficient mice, which can result in uncontrolled immune responses. Anti-CD72 antibody (Bu40) is essential for studying the intricate balance of immune activation and inhibition, providing insights into B cell biology and potential therapeutic targets for immune-related disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD72 Antibody (Bu40) | sc-80734 | 200 µg/ml | $322.00 | |||
CD72 Antibody (Bu40): m-IgG Fc BP-HRP Bundle | sc-539577 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD72 Antibody (Bu40): m-IgG2a BP-HRP Bundle | sc-546739 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD72 Antibody (Bu40) FITC | sc-80734 FITC | 200 µg/ml | $336.00 | |||
CD72 Antibody (Bu40) PE | sc-80734 PE | 200 µg/ml | $349.00 |