CD64 Antibody (C-6): sc-515431

CD64 Antibody (C-6) is a mouse monoclonal IgM antibody that detects CD64 of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD64 (C-6) antibody is available in a non-conjugated form, providing flexibility for various experimental needs. CD64, also known as Fc-gamma receptor 1, is a critical surface glycoprotein that exhibits high affinity for monomeric immunoglobulin G (IgG) and is predominantly expressed on monocytes and macrophages, with expression levels in neutrophils being inducible upon stimulation with interferon-gamma. CD64 plays a key role in mediating humoral immune responses, particularly in initiating cell-mediated cytotoxicity, which is essential for targeting and eliminating pathogens. Structurally, CD64 features an extracellular domain that binds IgG, and a cytoplasmic tail containing motifs that facilitate recruitment of signaling molecules, thereby triggering downstream immune responses. CD64 has been shown to interact with various proteins, including Src family kinases such as Hck and Lyn, which enhance signaling capabilities upon receptor cross-linking. This interaction highlights CD64′s significance in modulating immune cell activation and function, making anti-CD64 antibody (C-6) a valuable tool for researchers studying immune responses in mouse models.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD64 Antibody (C-6) References:

1. Neutrophil CD64 as a sepsis biomarker.  |  Hoffmann, JJ. 2011. Biochem Med (Zagreb). 21: 282-90. PMID: 22420242
2. CD64: An Attractive Immunotherapeutic Target for M1-type Macrophage Mediated Chronic Inflammatory Diseases.  |  Akinrinmade, OA., et al. 2017. Biomedicines. 5: PMID: 28895912
3. Neutrophil CD64 a Diagnostic and Prognostic Marker of Sepsis in Adult Critically Ill Patients: A Brief Review.  |  Patnaik, R., et al. 2020. Indian J Crit Care Med. 24: 1242-1250. PMID: 33446980
4. Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression.  |  Gravina, A., et al. 2023. Nat Biotechnol. 41: 717-727. PMID: 36593395
5. Serum CD64 as a Marker for Chronic Periprosthetic Joint Infection.  |  Yalamanchili, DR., et al. 2023. Arthroplast Today. 21: 101138. PMID: 37151405
6. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity.  |  Cui, Y., et al. 2023. Cell Rep. 42: 112797. PMID: 37436890
7. CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis.  |  Theeuwes, WF., et al. 2023. Arthritis Res Ther. 25: 158. PMID: 37653557
8. MICa/b-dependent activation of natural killer cells by CD64+ inflammatory type 2 dendritic cells contributes to autoimmunity.  |  Sánchez-Cerrillo, I., et al. 2023. EMBO J. 42: e113714. PMID: 37916875
9. An integrative model with HLA-DR, CD64, and PD-1 for the diagnostic and prognostic evaluation of sepsis.  |  Chen, G., et al. 2024. Immun Inflamm Dis. 12: e1138. PMID: 38270311
10. Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis.  |  Huang, X., et al. 2024. J Transl Med. 22: 218. PMID: 38424643

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD64 Antibody (C-6) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-CD64 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD64 Antibody (C-6) Specifications

Alternate Product Name: Fc-gamma receptor 1

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 46-67

Epitope Target: CD64

Epitope Species: mouse

Product Reactivity/Detection: CD64

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for CD64 Antibody (C-6): P: Blocking Peptide

The preferred CD64 antibody is CD64 Antibody (10.1): sc-1184.