CD58 Antibody (TS2/9.1.4.3): sc-20009
- CD58 Antibody (TS2/9.1.4.3) is a mouse monoclonal IgG1 κ CD58 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against human cytolytic T lymphocytes
- CD58 Antibody (TS2/9.1.4.3) is recommended for detection of CD58 of human origin by WB, IP and FCM
- Anti-CD58 Antibody (TS2/9.1.4.3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD58 Antibody (TS2/9.1.4.3) for WB applications. These reagents are now offered in bundles with CD58 Antibody (TS2/9.1.4.3) (see ordering information below).
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CD58 Antibody (TS2/9.1.4.3) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD58 protein of human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD58 (TS2/9.1.4.3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD58, also known as the CD2 ligand, plays a crucial role in immune response by facilitating cell adhesion through its interaction with CD2, a transmembrane glycoprotein expressed on T lymphocytes, natural killer cells, and thymocytes. This interaction is vital for enhancing antigen-specific T cell activation, which is essential for an effective immune response. CD58 is heavily glycosylated and exhibits a broad tissue distribution, being present in hematopoietic cells as well as endothelial cells, underscoring its importance in both immune function and cellular communication. CD58′s ability to mediate these interactions highlights its significance in immunological processes and potential implications in therapeutic strategies targeting immune modulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD58 Antibody (TS2/9.1.4.3) References:
- Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-1 in normal tissue. | Smith, ME. and Thomas, JA. 1990. J Clin Pathol. 43: 893-900. PMID: 1702102
- Role of lymphocyte adhesion receptors in transient interactions and cell locomotion. | Dustin, ML. and Springer, TA. 1991. Annu Rev Immunol. 9: 27-66. PMID: 1716919
- T-lymphocyte activation: the biology and function of CD2 and CD4. | Bierer, BE. and Burakoff, SJ. 1989. Immunol Rev. 111: 267-94. PMID: 2483402
- The structural biology of CD2. | Moingeon, P., et al. 1989. Immunol Rev. 111: 111-44. PMID: 2576417
- Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. | Beyers, AD., et al. 1989. Immunol Rev. 111: 59-77. PMID: 2576418
- Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. | Sanders, ME., et al. 1988. J Immunol. 140: 1401-7. PMID: 2894392
- The structure and ligand interactions of CD2: implications for T-cell function. | Davis, SJ. and van der Merwe, PA. 1996. Immunol Today. 17: 177-87. PMID: 8871350
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD58 Antibody (TS2/9.1.4.3) | sc-20009 | 200 µg/ml | $322.00 | |||
CD58 Antibody (TS2/9.1.4.3): m-IgG Fc BP-HRP Bundle | sc-526592 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD58 Antibody (TS2/9.1.4.3): m-IgG1 BP-HRP Bundle | sc-531965 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD58 Antibody (TS2/9.1.4.3) AC | sc-20009 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD58 Antibody (TS2/9.1.4.3) HRP | sc-20009 HRP | 200 µg/ml | $322.00 | |||
CD58 Antibody (TS2/9.1.4.3) FITC | sc-20009 FITC | 200 µg/ml | $336.00 | |||
CD58 Antibody (TS2/9.1.4.3) PE | sc-20009 PE | 200 µg/ml | $349.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 488 | sc-20009 AF488 | 200 µg/ml | $364.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 546 | sc-20009 AF546 | 200 µg/ml | $364.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 594 | sc-20009 AF594 | 200 µg/ml | $364.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 647 | sc-20009 AF647 | 200 µg/ml | $364.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 680 | sc-20009 AF680 | 200 µg/ml | $364.00 | |||
CD58 Antibody (TS2/9.1.4.3) Alexa Fluor® 790 | sc-20009 AF790 | 200 µg/ml | $364.00 |