CD55 Antibody (67): sc-53207
- CD55 Antibody (67) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against fibronectin purified monocytes of human origin
- recommended for detection of CD55 of mouse, rat and human origin by WB, IP and IF
- See CD55 (NaM16-4D3): sc-51733 for CD55 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD55 Antibody (67) for WB applications. These reagents are now offered in bundles with CD55 Antibody (67) (see ordering information below).
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CD55 Antibody (67) is a mouse monoclonal IgG1 antibody that detects CD55 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). CD55, also known as decay accelerating factor (DAF), is a GPI-anchored single-chain glycoprotein that plays a crucial role in regulating the complement system, which is essential for immune defense. By inhibiting the formation of the C3 convertase enzyme complex, CD55 prevents the amplification of the complement cascade, thereby protecting cells from complement-mediated lysis and the formation of the membrane attack complex. This protective function is particularly important in tissues exposed to serum, as CD55 is expressed on various cells, including both hematopoietic and non-hematopoietic cells. The ability of CD55 to modulate the immune response highlights its significance in maintaining cellular integrity and preventing unwanted tissue damage during immune reactions. Anti-CD55 antibody (67) provides a reliable tool for researchers studying the complement system and its implications in various diseases, including autoimmune disorders and transplant rejection.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD55 Antibody (67) References:
- CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. | Karpus, ON., et al. 2015. Arthritis Res Ther. 17: 6. PMID: 25596646
- CD55 is a HIF-2α marker with anti-adhesive and pro-invading properties in neuroblastoma. | Cimmino, F., et al. 2016. Oncogenesis. 5: e212. PMID: 27043658
- Hypoxia-Inducible Factor-1α Regulates CD55 in Airway Epithelium. | Pandya, PH., et al. 2016. Am J Respir Cell Mol Biol. 55: 889-898. PMID: 27494303
- Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy. | Kurolap, A., et al. 2017. N Engl J Med. 377: 87-89. PMID: 28657861
- Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer. | Lin, WD., et al. 2021. Cancer Immunol Res. 9: 113-122. PMID: 33177111
- CD55-deficiency in Jews of Bukharan descent is caused by the Cromer blood type Dr(a-) variant. | Kurolap, A., et al. 2023. Hum Genet. 142: 683-690. PMID: 35314883
- Correction of a CD55 mutation to quantify the efficiency of targeted knock-in via flow cytometry. | Rahman, ML., et al. 2022. Mol Biol Rep. 49: 6241-6248. PMID: 35420385
- CD55 is upregulated by cAMP/PKA/AKT and modulates human decidualization via Src and ERK pathway and decidualization-related genes. | Tang, Z., et al. 2022. Mol Reprod Dev. 89: 256-268. PMID: 35474595
- Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue. | Couchet, M., et al. 2023. Adipocyte. 2283213. PMID: 37982546
- The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells. | Lee, I., et al. 2024. bioRxiv.. PMID: 38496511
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD55 Antibody (67) | sc-53207 | 200 µg/ml | $322.00 | |||
CD55 Antibody (67): m-IgG Fc BP-HRP Bundle | sc-538979 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD55 Antibody (67): m-IgG1 BP-HRP Bundle | sc-541190 | 200 µg Ab; 20 µg BP | $361.00 |