CD53 Antibody (202-24b): sc-21778
- CD53 Antibody (202-24b) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- recommended for detection of CD53 of human origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD53 Antibody (202-24b). These reagents are now offered in bundles with CD53 Antibody (202-24b) (see ordering information below).
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CD53 Antibody (202-24b) is a mouse monoclonal IgG1 antibody that detects CD53 protein of human origin by flow cytometry (FCM). CD53 is a crucial member of the tetraspanin membrane protein family, which plays a significant role in various cellular processes, including cell activation, signal transduction, and cell adhesion. Anti-CD53 antibody (202-24b) recognizes a protein predominantly expressed in the lymphoid-myeloid lineage, particularly on B cells, monocytes, macrophages, neutrophils, and T cells, where CD53 contributes to immune responses and cell communication. The structure of CD53, characterized by its four transmembrane domains, allows CD53 to interact with other membrane proteins, forming complexes that facilitate signaling pathways essential for immune cell function. Notably, CD53 has been implicated in the regulation of cell motility and metastasis, acting as a metastasis suppressor by inhibiting tumor cell movement. The N-glycosylation of CD53 further enhances stability and functionality, making CD53 a vital target for studies related to immune responses and cancer biology. CD53 monoclonal antibody (202-24b) is an invaluable tool for researchers investigating the dynamics of immune cell populations and their roles in health and disease.
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CD53 Antibody (202-24b) References:
- The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. | Greenberg, ZJ., et al. 2020. J Immunol. 204: 58-67. PMID: 31748347
- Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression. | Demaria, MC., et al. 2020. iScience. 23: 101104. PMID: 32428859
- The regulation and function of CD20: an 'enigma' of B-cell biology and targeted therapy. | Pavlasova, G. and Mraz, M. 2020. Haematologica. 105: 1494-1506. PMID: 32482755
- Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis. | Sun, S., et al. 2021. Blood. 138: 1211-1224. PMID: 34115843
- Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice. | Yeung, L., et al. 2021. Immunol Cell Biol. 99: 1053-1066. PMID: 34514627
- Tetraspanin CD53 controls T cell immunity through regulation of CD45RO stability, mobility, and function. | Dunlock, VE., et al. 2022. Cell Rep. 39: 111006. PMID: 35767951
- The tetraspanin CD53 protects stressed hematopoietic stem cells via promotion of DREAM complex-mediated quiescence. | Greenberg, ZJ., et al. 2023. Blood. 141: 1180-1193. PMID: 36542833
- The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes. | Higgins, CB., et al. 2023. J Biol Chem. 299: 102835. PMID: 36581203
- CD53 sends HSCs to sweet DREAMs. | Karabacz, N. and Cabezas-Wallscheid, N. 2023. Blood. 141: 1100-1101. PMID: 36893005
- PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation. | Kar, P., et al. 2024. EMBO J. 43: 2929-2953. PMID: 38834853
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD53 Antibody (202-24b) | sc-21778 | 200 µg/ml | $322.00 | |||
CD53 Antibody (202-24b): m-IgG Fc BP-HRP Bundle | sc-536670 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD53 Antibody (202-24b): m-IgGκ BP-HRP Bundle | sc-533829 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD53 Antibody (202-24b): m-IgG1 BP-HRP Bundle | sc-544752 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD53 Antibody (202-24b) FITC | sc-21778 FITC | 200 µg/ml | $336.00 | |||
CD53 Antibody (202-24b) PE | sc-21778 PE | 200 µg/ml | $349.00 |