CD5 Antibody (OX19): sc-53054

CD5 Antibody (OX19) is a mouse monoclonal IgG1 antibody that detects CD5 in mouse and rat samples through applications such as immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CD5 is a crucial transmembrane glycoprotein predominantly expressed on T lymphocytes, where CD5 (OX19) monoclonal antibody plays a significant role in modulating T cell activation and survival. Located on the surface of these immune cells, CD5 interacts with the T cell receptor (TCR) and the CD3-ζ chain, facilitating a complex signaling cascade that influences T cell responses. CD5′s presence is essential for maintaining T cell homeostasis, as CD5′s absence can lead to hyper-responsiveness to TCR-mediated activation, potentially resulting in autoimmune disorders. CD5′s interaction with the Src family kinase Lck enhances the kinase′s activity, which is vital for effective T cell signaling. CD5′s binding to CD72 is also of interest, as this interaction may play a role in thymic selection, although the exact consequences remain an area of ongoing research. With critical functions in immune regulation, anti-CD5 antibody (OX19) serves as an invaluable tool for studying T cell biology and related immunological processes.

The preferred CD5 antibody is CD5 Antibody (UCH-T2): sc-1180.