CD48 Antibody (0.N.139): sc-70718

CD48 Antibody (0.N.139) is a mouse monoclonal IgG1 antibody that detects CD48 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CD48 is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that plays a crucial role in immune regulation by acting as a low-affinity receptor for CD2, facilitating interactions between immune cells. CD48 is predominantly expressed on peripheral blood T cells, B cells, null cells, thymocytes, eosinophils, and certain epithelial cells, highlighting CD48′s importance in immune responses. Additionally, CD48 is found on hematopoietic and endothelial cells in rats, while in mice, CD48 is present on thymocytes, lymph node cells, most macrophages, and bone marrow cells. CD48′s interaction with the tyrosine kinase Lck is particularly significant, as this suggests a role in T cell activation and signaling pathways, making CD48 a vital component in the modulation of immune responses. Anti-CD48 antibody (0.N.139) is an essential tool for researchers studying immune cell interactions and the underlying mechanisms of immune regulation.

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CD48 Antibody (0.N.139) References:

1. 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.  |  McNerney, ME., et al. 2005. Blood. 106: 1337-40. PMID: 15870174
2. Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.  |  Lee, KM., et al. 2006. Blood. 107: 3181-8. PMID: 15905190
3. Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells.  |  Mathew, SO., et al. 2005. J Immunol. 175: 1005-13. PMID: 16002700
4. No association of polymorphisms in human endogenous retrovirus K18 and CD48 with schizophrenia.  |  Nyegaard, M., et al. 2012. Psychiatr Genet. 22: 146-8. PMID: 22495247
5. Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.  |  Kis-Toth, K. and Tsokos, GC. 2014. J Immunol. 192: 4436-42. PMID: 24670806
6. Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1.  |  Ziblat, A., et al. 2021. Front Immunol. 12: 681615. PMID: 34149719
7. Costimulation by CD48 and B7-1 induces immunity against poorly immunogenic tumors.  |  Li, Y., et al. 1996. J Exp Med. 183: 639-44. PMID: 8627175
8. Prolonged allograft survival by the inhibition of costimulatory CD2 signals but not by modulation of CD48 (CD2 ligand) in the rat.  |  Sido, B., et al. 1996. Transpl Int. 9 Suppl 1: S323-7. PMID: 8959856
9. Identification of the 2B4 molecule as a counter-receptor for CD48.  |  Latchman, Y., et al. 1998. J Immunol. 161: 5809-12. PMID: 9834056
10. CD48 expression on leukocytes in infectious diseases: flow cytometric analysis of surface antigen.  |  Katsuura, M., et al. 1998. Acta Paediatr Jpn. 40: 580-5. PMID: 9893294

The preferred CD48 antibody is CD48 Antibody (5-4.8): sc-8400.