CD46 Antibody (M177): sc-52647
- CD46 Antibody (M177) is a mouse monoclonal IgG1 κ, cited in 11 publications, provided at 200 µg/ml
- raised against CD46 of human origin
- recommended for detection of CD46 of human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to FITC for IF, IHC(P) and FCM
- See CD46 (C-10): sc-166159 for CD46 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD46 Antibody (M177) for WB and IHC(P) applications. These reagents are now offered in bundles with CD46 Antibody (M177) (see ordering information below).
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CD46 Antibody (M177) is a mouse monoclonal IgG1 antibody that detects CD46 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD46, also known as membrane cofactor protein (MCP), is a crucial transmembrane glycoprotein that plays a significant role in regulating the complement cascade, which is vital for the immune response. By inhibiting the deposition of complement proteins C3b and C4b on self-tissues, CD46 prevents unwanted complement activation that could lead to tissue damage and autoimmune diseases. CD46′s function as a cofactor for factor I, which degrades C3b and C4b, is essential for maintaining immune homeostasis. CD46 is expressed on a wide range of immune and non-immune cells, including thymocytes, T cells, B cells, monocytes, and epithelial cells, highlighting CD46′s importance in both immune regulation and viral entry, as CD46 serves as the primary receptor for measles virus and human herpes virus. The presence of CD46 on these diverse cell types underscores CD46′s critical role in both health and disease, making anti-CD46 antibody (M177) an invaluable tool for researchers studying immune responses and viral pathogenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD46 Antibody (M177) References:
- T-cell regulation by CD46 and its relevance in multiple sclerosis. | Astier, AL. 2008. Immunology. 124: 149-54. PMID: 18384356
- CD46 signaling in T cells: linking pathogens with polarity. | Hawkins, ED. and Oliaro, J. 2010. FEBS Lett. 584: 4838-44. PMID: 20828571
- CD46 accelerates macrophage-mediated host susceptibility to meningococcal sepsis in a murine model. | Wang, X., et al. 2017. Eur J Immunol. 47: 119-130. PMID: 27794168
- MicroRNAs regulating cluster of differentiation 46 (CD46) in cardioembolic and non-cardioembolic stroke. | Tan, JR., et al. 2017. PLoS One. 12: e0172131. PMID: 28199366
- Targeting CD46 Enhances Anti-Tumoral Activity of Adenovirus Type 5 for Bladder Cancer. | Do, MH., et al. 2018. Int J Mol Sci. 19: PMID: 30201920
- Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET. | Wang, S., et al. 2021. Clin Cancer Res. 27: 1305-1315. PMID: 33293372
- CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity. | Do, MH., et al. 2022. Sci Rep. 12: 22420. PMID: 36575233
- The CD46 ectodomain participates in human cytomegalovirus infection of epithelial cells. | Parsons, AJ., et al. 2023. J Gen Virol. 104: PMID: 37668349
- Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9. | Thi, TN., et al. 2024. Int J Oncol. 65: PMID: 38847230
- Morbillivirus downregulation of CD46. | Galbraith, SE., et al. 1998. J Virol. 72: 10292-7. PMID: 9811778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD46 Antibody (M177) | sc-52647 | 200 µg/ml | $322.00 | |||
CD46 Antibody (M177): m-IgG Fc BP-HRP Bundle | sc-536860 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD46 Antibody (M177): m-IgGκ BP-HRP Bundle | sc-534027 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD46 Antibody (M177): m-IgG1 BP-HRP Bundle | sc-544862 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD46 Antibody (M177) FITC | sc-52647 FITC | 200 µg/ml | $336.00 |