CD45R Antibody (6B6): sc-73537

CD45R Antibody (6B6) is a mouse monoclonal IgG2b antibody engineered to recognize CD45R. CD45R is a transmembrane glycoprotein that is widely expressed across various hematopoietic cells and plays a pivotal role in the immune system. CD45R exists in multiple isoforms generated through alternative splicing of exons 4, 5, and 6, which primarily affect its extracellular domain, while the intracellular domain remains conserved. This structural variation is essential for diverse functions in different immune cell types, allowing CD45R to participate in various signaling pathways. Post-translational modifications of CD45R, such as glycosylation, are critical for stability, localization, and interaction with other proteins, thereby influencing phosphotyrosine phosphatase activity. Anti-CD45R antibody (6B6) is raised against low-density cells from AO/G rat Peyer′s patches, ensuring effectiveness in recognizing CD45R in both mouse and rat species through applications like western blotting (WB), immunoprecipitation (IP), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD45R functions as a vital regulator of tyrosine phosphorylation initiated by the TCR/CD3 complex, which is essential for the activation and signaling of Src and Syk family kinases, including key proteins such as Lck, Fyn, and ZAP-70. Understanding the post-translational modifications of CD45R is crucial for elucidating its role in immune cell signaling and function. CD45R monoclonal antibody (6B6) is an indispensable tool for researchers investigating immune responses, signaling mechanisms, and the behavior of hematopoietic cells, providing valuable insights into the regulation and modulation of the immune system.

The preferred CD45 antibody is CD45 Antibody (35-Z6): sc-1178.