CD43 Antibody (84-3C1): sc-21774

CD43 Antibody (84-3C1) is a mouse monoclonal IgG1 antibody that detects CD43 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD43, also known as leukosialin, is a major O-glycosylated sialoglycoprotein predominantly found on the surface of leukocytes, where CD43 plays a crucial role in cellular adhesion and immune response regulation. CD43 is a member of the surface mucin family and is involved in the modulation of cell-cell interactions, which is vital for maintaining proper immune function and preventing excessive inflammation. Notably, CD43 is recognized as a negative regulator of cellular adhesion, meaning CD43 can inhibit the binding of leukocytes to other cells and extracellular matrix components, thereby influencing processes such as tumor progression and immune evasion. CD43′s ability to interact with specific proteins, such as selectins, further underscores CD43′s importance in mediating leukocyte trafficking and migration during immune responses. Anti-CD43 antibody (84-3C1) is an essential tool for researchers studying T cell biology, cancer immunology, and the intricate mechanisms of immune regulation.

The preferred CD43 antibody is CD43 Antibody (DF-T1): sc-6256.