CD42b Antibody (PM6/40): sc-59051

CD42b Antibody (PM6/40) is a mouse monoclonal IgG1 antibody that detects CD42b in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD42b, also known as glycoprotein Ib α (GPIb α), is a crucial membrane glycoprotein that plays a significant role in hemostasis by serving as a receptor for von Willebrand′s factor, which is essential for platelet adhesion to the vascular endothelium during injury. The interaction between CD42b and von Willebrand′s factor is vital for the formation of a stable platelet plug, thereby preventing excessive bleeding. This receptor is composed of α and β chains, with the β chain also referred to as CD42γ, and is predominantly expressed on platelets and megakaryocytes. The presence of CD42b complex on the platelet surface is critical for initiating the clotting process, making CD42b a key target for studies related to thrombosis and bleeding disorders. Anti-CD42b antibody (PM6/40) is an invaluable tool for researchers investigating the mechanisms of platelet function and the pathophysiology of related diseases.

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CD42b Antibody (PM6/40) References:

1. Use of CD42b immunohistochemical stain for the detection of Histoplasma.  |  Ku, NK., et al. 2018. Ann Diagn Pathol. 32: 47-50. PMID: 29414398
2. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.  |  Malehmir, M., et al. 2019. Nat Med. 25: 641-655. PMID: 30936549
3. CD42b Immunostaining as a Marker for Placental Fibrinoid in Normal Pregnancy and Complications.  |  Zhang, P. 2021. Fetal Pediatr Pathol. 40: 387-394. PMID: 31986954
4. Increased circulating CD31+/CD42b-EMPs in Perthes disease and inhibit HUVECs angiogenesis via endothelial dysfunction.  |  Li, B., et al. 2021. Life Sci. 265: 118749. PMID: 33220290
5. S100A8/A9 drives the formation of procoagulant platelets through GPIbα.  |  Colicchia, M., et al. 2022. Blood. 140: 2626-2643. PMID: 36026606
6. Dual roles of fucoidan-GPIbα interaction in thrombosis and hemostasis: implications for drug development targeting GPIbα.  |  Shen, C., et al. 2023. J Thromb Haemost. 21: 1274-1288. PMID: 36732162
7. GPIbα-filamin A interaction regulates megakaryocyte localization and budding during platelet biogenesis.  |  Ellis, ML., et al. 2024. Blood. 143: 342-356. PMID: 37922495
8. GPIbα CAAR T cells function like a Trojan horse to eliminate autoreactive B cells to treat immune thrombocytopenia.  |  Zhou, J., et al. 2024. Haematologica. 109: 2256-2270. PMID: 38299614
9. WY-14643, a novel antiplatelet and antithrombotic agent targeting the GPIbα receptor.  |  Cao, C., et al. 2024. Thromb Res. 238: 41-51. PMID: 38669962
10. Shedding light on GPIbα shedding.  |  Debaene, C., et al. 2024. Curr Opin Hematol. 31: 224-229. PMID: 38728102

The preferred CD42b antibody is CD42b Antibody (SZ2): sc-59052.