CD42b Antibody (MM2/174): sc-80728

CD42b Antibody (MM2/174) is a mouse monoclonal IgG1 antibody that detects CD42b of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD42b antibody (MM2/174) is available in non-conjugated form, providing flexibility for various experimental needs. CD42b, also known as glycoprotein Ib α (GPIb α), is a membrane glycoprotein composed of α and β chains, with the β chain also referred to as CD42c. CD42b (MM2/174) antibody recognizes a protein predominantly expressed on platelets and megakaryocytes, where CD42b plays a vital role in hemostasis. CD42b complex, in conjunction with CD42a, serves as a receptor for von Willebrand′s factor, facilitating platelet adhesion to the vascular endothelium during injury. This interaction is essential for the formation of a stable platelet plug, making CD42b a key player in the regulation of blood clotting and maintaining vascular integrity. Understanding CD42b function is critical for developing therapeutic strategies for bleeding disorders and thrombotic diseases, highlighting anti-CD42b antibody (MM2/174) importance in research and clinical applications.

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CD42b Antibody (MM2/174) References:

1. GpIbα interacts exclusively with exosite II of thrombin.  |  Lechtenberg, BC., et al. 2014. J Mol Biol. 426: 881-93. PMID: 24316004
2. Platelet Reactivity in Patients With Stroke and Hyperlipidemia, GPIbα Assessment.  |  Pawelczyk, M., et al. 2016. Clin Appl Thromb Hemost. 22: 166-70. PMID: 25063764
3. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα.  |  Wang, Y., et al. 2017. Nat Commun. 8: 15559. PMID: 28555620
4. Dengue Virus Induces the Release of sCD40L and Changes in Levels of Membranal CD42b and CD40L Molecules in Human Platelets.  |  Núñez-Avellaneda, D., et al. 2018. Viruses. 10: PMID: 29976871
5. Humanized GPIbα-von Willebrand factor interaction in the mouse.  |  Kanaji, S., et al. 2018. Blood Adv. 2: 2522-2532. PMID: 30287479
6. GPIbα is the driving force of hepatic thrombopoietin generation.  |  Karakas, D., et al. 2021. Res Pract Thromb Haemost. 5: e12506. PMID: 33977209
7. The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling.  |  Constantinescu-Bercu, A., et al. 2022. Haematologica. 107: 933-946. PMID: 34134470
8. Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP.  |  Shao, B., et al. 2022. Blood. 139: 2523-2533. PMID: 35157766
9. Development of antithrombotic peptides based on the molecular interactions between von Willebrand factor and GPIbα.  |  Chen, R., et al. 2022. Phys Chem Chem Phys. 24: 22670-22678. PMID: 36106495
10. Low α-Thrombin/GPIbα Interaction Is a Potential Contributor to Platelet Hyper-reactivity in COVID-19 Patients.  |  Zaid, Y., et al. 2023. Thromb Haemost. 123: 804-807. PMID: 37044132

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD42b Antibody (MM2/174) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD42b Antibody (MM2/174) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD42b Antibody (MM2/174) Specifications

Alternate Product Name: CD42b

Product Clone Name: MM2/174

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CD42b

Epitope Species: human

Product Reactivity/Detection: CD42b

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% stabilizer protein and 1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD42b Antibody (MM2/174): N/A

The preferred CD42b antibody is CD42b Antibody (SZ2): sc-59052.