CD4 Antibody (18-46): sc-1176

CD4 Antibody (18-46) is a mouse monoclonal IgG2b kappa light chain antibody, specifically designed to target the human CD4 protein, also known as T4 or Leu 3. Anti-CD4 antibody (18-46) is recommended for use in immunofluorescence (IF) and flow cytometry (FCM) applications, effectively recognizing CD4 expressed on various human cell types including T helper cells, cortical cells, mature medullary thymocytes, microglial cells, and dendritic cells. CD4 is a membrane glycoprotein composed of four extracellular immunoglobulin-like domains, playing a crucial role in the immune system by enhancing the binding affinity between the T cell receptor (TCR) and class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells. This interaction is essential for effective T cell activation and signal transduction, facilitating robust immune responses against pathogens. Additionally, CD4 serves as a primary receptor for the human immunodeficiency virus (HIV), making CD4 a pivotal target in studies of viral entry and immune system impairment. CD4 monoclonal antibody (18-46) is instrumental in both research and clinical settings for identifying and characterizing CD4-positive cells, thereby contributing to advancements in immunology and therapeutic development. Anti-CD4 antibody (18-46) supports critical research in areas such as autoimmune diseases, infectious diseases, and immunotherapy.

The preferred CD4 antibody is CD4 Antibody (GK1.5): sc-13573.