CD39L4 Antibody (C-6): sc-377172

CD39L4 Antibody (C-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects CD39L4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CD39L4 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD39L4, also known as ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), is a 428 amino acid integral membrane glycoprotein that plays a crucial role in the endoplasmic reticulum (ER) by facilitating the reglycosylation of glycoproteins, which is essential for proper protein folding and quality control within the ER. This localization ensures that only correctly folded proteins are transported to their final destinations, thereby maintaining cellular homeostasis. CD39L4 is highly expressed in tissues such as the colon, testis, kidney, liver, and prostate, and CD39L4 overexpression has been linked to the development of breast, testicular, and prostate cancers, indicating a potential role as a proto-oncogene in carcinogenesis. Anti-CD39L4 antibody (C-6) is an invaluable tool for researchers studying the functional implications of CD39L4 in various biological processes and disease states.

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CD39L4 Antibody (C-6) References:

1. Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1.  |  Recio, JA., et al. 2000. Cancer Res. 60: 1720-8. PMID: 10749145
2. Expression of the protein product of the PCPH proto-oncogene in human tumor cell lines.  |  Rouzaut, A., et al. 2001. Radiat Res. 155: 181-187. PMID: 11121232
3. Identity between the PCPH proto-oncogene and the CD39L4 (ENTPD5) ectonucleoside triphosphate diphosphohydrolase gene.  |  Páez, JG., et al. 2001. Int J Oncol. 19: 1249-54. PMID: 11713596
4. Gradual deregulation and loss of PCPH expression in the progression of human laryngeal neoplasia.  |  Blánquez, MJ., et al. 2002. Mol Carcinog. 35: 186-95. PMID: 12489110
5. Deregulated expression of the PCPH proto-oncogene in human breast cancers.  |  Blánquez, MJ., et al. 2004. Int J Oncol. 25: 821-30. PMID: 15375529
6. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase.  |  Murphy-Piedmonte, DM., et al. 2005. Biochim Biophys Acta. 1747: 251-9. PMID: 15698960
7. PCPH expression is an early event in the development of testicular germ cell tumors.  |  Regadera, J., et al. 2006. Int J Oncol. 28: 595-604. PMID: 16465363
8. PCPH/ENTPD5 expression enhances the invasiveness of human prostate cancer cells by a protein kinase C delta-dependent mechanism.  |  Villar, J., et al. 2007. Cancer Res. 67: 10859-68. PMID: 18006831
9. E-NTPDases and ecto-5'-nucleotidase expression profile in rat heart left ventricle and the extracellular nucleotide hydrolysis by their nerve terminal endings.  |  Rücker, B., et al. 2008. Life Sci. 82: 477-86. PMID: 18201730

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD39L4 Antibody (C-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD39L4 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD39L4 Antibody (C-6) Specifications

Alternate Product Name: CD39L4

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 251-329

Epitope Target: CD39L4

Epitope Species: human

Product Reactivity/Detection: CD39L4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD39L4 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin