CD38 Antibody (2Q1628): sc-70654

CD38 Antibody (2Q1628) is a rat monoclonal IgG2a antibody that detects CD38 in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. CD38 is a type II integral membrane glycoprotein predominantly expressed on early B and T cell lineages, activated B and T cells, and various other immune cells, including thymocytes, pre-B cells, germinal center B cells, and Ig-secreting plasma cells. CD38′s presence is notably absent in most mature resting peripheral lymphocytes, highlighting CD38′s role in immune activation. CD38 functions as a NAD glycohydrolase, playing a crucial role in T lymphocyte activation, proliferation, and differentiation, while also mediating apoptosis in myeloid and lymphoid progenitor cells. CD38 acts as both a signaling receptor and an enzyme that generates calcium-mobilizing metabolites, such as cyclic adenosine diphosphate ribose (cADPR), which are vital for intracellular signaling pathways. CD38 is essential for the survival of invariant natural killer T (iNKT) cells, which are key players in maintaining immunological tolerance, thereby underscoring CD38′s significance in both adaptive and innate immune responses. Anti-CD38 antibody (2Q1628) is an invaluable tool for researchers studying immune cell dynamics and signaling pathways in mouse models.

The preferred CD38 antibody is CD38 Antibody (AT13/5): sc-59028.